VAŇÁČOVÁ, Štěpánka a Richard ŠTEFL. The exosome and RNA quality control in the nucleus. EMBO REPORTS. Nature Publishing Group, London, UK: Nature Publishing Group, London, UK, 2007, roč. 8, č. 7, s. 651-657. ISSN 1469-221X. |
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@article{719399, author = {Vaňáčová, Štěpánka and Štefl, Richard}, article_location = {Nature Publishing Group, London, UK}, article_number = {7}, keywords = {RNA decay; exoribonuclease; exosome; structure; nuclear polyadenylation; TRAMP}, language = {eng}, issn = {1469-221X}, journal = {EMBO REPORTS}, title = {The exosome and RNA quality control in the nucleus}, volume = {8}, year = {2007} }
TY - JOUR ID - 719399 AU - Vaňáčová, Štěpánka - Štefl, Richard PY - 2007 TI - The exosome and RNA quality control in the nucleus JF - EMBO REPORTS VL - 8 IS - 7 SP - 651-657 EP - 651-657 PB - Nature Publishing Group, London, UK SN - 1469221X KW - RNA decay KW - exoribonuclease KW - exosome KW - structure KW - nuclear polyadenylation KW - TRAMP N2 - To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity. ER -
VAŇÁČOVÁ, Štěpánka a Richard ŠTEFL. The exosome and RNA quality control in the nucleus. \textit{EMBO REPORTS}. Nature Publishing Group, London, UK: Nature Publishing Group, London, UK, 2007, roč.~8, č.~7, s.~651-657. ISSN~1469-221X.
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