| MARROTE, Karine, Charles SABIN, Cathy PRÉVILLE, Myriam MOUMÉ-PYMBOCK, Michaela WIMMEROVÁ, Edward P. MITCHELL, Anne IMBERTY and René ROY. X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives. ChemMedChem. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2007, vol. 2, No 9, p. 1328-1338. ISSN 1860-7187. |
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@article{720870,
author = {Marrote, Karine and Sabin, Charles and Préville, Cathy and MouméandPymbock, Myriam and Wimmerová, Michaela and Mitchell, Edward P. and Imberty, Anne and Roy, René},
article_location = {Weinheim},
article_number = {9},
keywords = {Pseudomonas aeruginosa; lectin; inhibitors; structure; thermodynamics},
language = {eng},
issn = {1860-7187},
journal = {ChemMedChem},
title = {X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives},
volume = {2},
year = {2007}
}
TY - JOUR
ID - 720870
AU - Marrote, Karine - Sabin, Charles - Préville, Cathy - Moumé-Pymbock, Myriam - Wimmerová, Michaela - Mitchell, Edward P. - Imberty, Anne - Roy, René
PY - 2007
TI - X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives
JF - ChemMedChem
VL - 2
IS - 9
SP - 1328-1338
EP - 1328-1338
PB - WILEY-VCH Verlag GmbH & Co. KGaA
SN - 18607187
KW - Pseudomonas aeruginosa
KW - lectin
KW - inhibitors
KW - structure
KW - thermodynamics
N2 - Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotherapies. PA-IIL lectin (LecB) from P.aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for l-fucose and related oligosaccharides. In the work presented herein, the disaccharide aFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives. Microcalorimetry and structural studies indicate that several of the derivatives are potent inhibitors of the lectin, with affinity in the same range as the best known natural ligand, Lewis a, and could represent interesting leads for the development of future antibacterial compounds.
ER -
MARROTE, Karine, Charles SABIN, Cathy PRÉVILLE, Myriam MOUMÉ-PYMBOCK, Michaela WIMMEROVÁ, Edward P. MITCHELL, Anne IMBERTY and René ROY. X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives. \textit{ChemMedChem}. Weinheim: WILEY-VCH Verlag GmbH \&{} Co. KGaA, 2007, vol.~2, No~9, p.~1328-1338. ISSN~1860-7187.
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