| REESE, Marcel, Victor M SANCHEZ-PEDREGAL, Karel KUBÍČEK, Jens MEILER, Marcel J BLOMMERS, Christian GRIESINGER a Teresa CARLOMAGNO. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. Angewandte Chemie International Edition. Weinheim: Wiley-VCH Verlag GmbH & Co., 2007, roč. 46, č. 11, s. 1864-1868. ISSN 1433-7851. |
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@article{724898,
author = {Reese, Marcel and SanchezandPedregal, Victor M and Kubíček, Karel and Meiler, Jens and Blommers, Marcel J and Griesinger, Christian and Carlomagno, Teresa},
article_location = {Weinheim},
article_number = {11},
keywords = {epothilones; NMR spectroscopy; structure elucidation; structure-activity relationships; tubulins},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution},
url = {http://www3.interscience.wiley.com/cgi-bin/abstract/114109930/ABSTRACT},
volume = {46},
year = {2007}
}
TY - JOUR
ID - 724898
AU - Reese, Marcel - Sanchez-Pedregal, Victor M - Kubíček, Karel - Meiler, Jens - Blommers, Marcel J - Griesinger, Christian - Carlomagno, Teresa
PY - 2007
TI - Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
JF - Angewandte Chemie International Edition
VL - 46
IS - 11
SP - 1864-1868
EP - 1864-1868
PB - Wiley-VCH Verlag GmbH & Co.
SN - 14337851
KW - epothilones
KW - NMR spectroscopy
KW - structure elucidation
KW - structure-activity relationships
KW - tubulins
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114109930/ABSTRACT
N2 - Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel.
ER -
REESE, Marcel, Victor M SANCHEZ-PEDREGAL, Karel KUBÍČEK, Jens MEILER, Marcel J BLOMMERS, Christian GRIESINGER a Teresa CARLOMAGNO. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. \textit{Angewandte Chemie International Edition}. Weinheim: Wiley-VCH Verlag GmbH \&{} Co., 2007, roč.~46, č.~11, s.~1864-1868. ISSN~1433-7851.
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