JONES, Sarah, Margaret FLORENCE, Ian ELLIS, Kateřina KAŇKOVÁ, Seth SCHOR and Ana SCHOR. Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI). Experimental Cell Research. Elsevier, 2007, vol. 313, No 20, p. 4145-4157. ISSN 0014-4827.
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Basic information
Original name Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)
Name in Czech Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)
Authors JONES, Sarah (826 United Kingdom of Great Britain and Northern Ireland), Margaret FLORENCE (826 United Kingdom of Great Britain and Northern Ireland), Ian ELLIS (826 United Kingdom of Great Britain and Northern Ireland), Kateřina KAŇKOVÁ (203 Czech Republic, guarantor), Seth SCHOR (826 United Kingdom of Great Britain and Northern Ireland) and Ana SCHOR (826 United Kingdom of Great Britain and Northern Ireland).
Edition Experimental Cell Research, Elsevier, 2007, 0014-4827.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.695
RIV identification code RIV/00216224:14110/07:00022626
Organization unit Faculty of Medicine
UT WoS 000251358200006
Keywords in English MSF; NGAL; lipocalin; keratinocytes; fibroblasts; HaCat
Tags fibroblasts, HaCat, keratinocytes, LIPOCALIN, MSF, NGAL
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Kateřina Kaňková, Ph.D., učo 2524. Changed: 23/6/2009 09:22.
Abstract
Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.
Abstract (in Czech)
Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.
Links
LZ1K03019, research and development projectName: Zlepšení hojení ran u pacientů s diabetem: preklinické ověření role proteinu MSF
Investor: Ministry of Education, Youth and Sports of the CR
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