| ZITTERBART, Karel, Iva ZAVŘELOVÁ, Jitka KADLECOVÁ, Renata SPĚŠNÁ, Adéla KRATOCHVÍLOVÁ, Zdeněk PAVELKA a Jaroslav ŠTĚRBA. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. Acta Neuropathologica. Berlin / Heidelberg: Springer, 2007, roč. 114, č. 6, s. 641-650. ISSN 0001-6322. |
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@article{726065,
author = {Zitterbart, Karel and Zavřelová, Iva and Kadlecová, Jitka and Spěšná, Renata and Kratochvílová, Adéla and Pavelka, Zdeněk and Štěrba, Jaroslav},
article_location = {Berlin / Heidelberg},
article_number = {6},
keywords = {Medulloblastoma - Isoforms of p73 protein - TP73 - Cerebellum - Prognosis},
language = {eng},
issn = {0001-6322},
journal = {Acta Neuropathologica},
title = {p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival.},
url = {http://www.springerlink.com/content/k1x61238un71m343/},
volume = {114},
year = {2007}
}
TY - JOUR
ID - 726065
AU - Zitterbart, Karel - Zavřelová, Iva - Kadlecová, Jitka - Spěšná, Renata - Kratochvílová, Adéla - Pavelka, Zdeněk - Štěrba, Jaroslav
PY - 2007
TI - p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival.
JF - Acta Neuropathologica
VL - 114
IS - 6
SP - 641-650
EP - 641-650
PB - Springer
SN - 00016322
KW - Medulloblastoma - Isoforms of p73 protein - TP73 - Cerebellum - Prognosis
UR - http://www.springerlink.com/content/k1x61238un71m343/
N2 - The human p73 protein is essential for normal morphogenesis and maintenance of neural tissue. Recently, several TP73 transcripts have been revealed in medulloblastoma (MB), the most common malignant brain tumor in children. Here, we performed immunohistochemical analysis on 29 MB specimens using anti-p73alpha and anti-DeltaNp73 antibodies. Our results indicate the involvement of p73 protein in MB tumorigenesis and define TP73 as a potential prognostic and therapeutic target for medulloblastoma.
ER -
ZITTERBART, Karel, Iva ZAVŘELOVÁ, Jitka KADLECOVÁ, Renata SPĚŠNÁ, Adéla KRATOCHVÍLOVÁ, Zdeněk PAVELKA a Jaroslav ŠTĚRBA. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. \textit{Acta Neuropathologica}. Berlin / Heidelberg: Springer, 2007, roč.~114, č.~6, s.~641-650. ISSN~0001-6322.
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