ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC
FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS
STEM CELL TRANSPLANTATION

D 2007

ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR et. al.

Základní údaje

Originální název

ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION

Název česky

Asociácia chromozómových zmien a štantdardných prognostických faktorov u pacientov s mnohopočetným myelomom liečených autológnou transplantáciou

Autoři

GREŠLIKOVÁ, Henrieta (703 Slovensko), Hana FILKOVÁ (203 Česká republika), Petr KUGLÍK (203 Česká republika, garant), Alexandra OLTOVÁ (203 Česká republika), Luděk POUR (203 Česká republika), Zdeněk ADAM (203 Česká republika), Andrea KŘIVANOVÁ (203 Česká republika), Marta KREJČÍ (203 Česká republika), Jana SMEJKALOVÁ (203 Česká republika) a Roman HÁJEK (203 Česká republika)

Vydání

Volume 92, supplement no.1. Pavia, Italy, Hematologica/The Hematology Journal, od s. 497-497, 1 s. 2007

Nakladatel

Ferrata-Storti Foundation

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.516

Kód RIV

RIV/00216224:14110/07:00019110

Organizační jednotka

Lékařská fakulta

ISSN

UT WoS

000247176901599

Klíčová slova anglicky

Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion

Štítky

13q deletion, 17p13 deletion, cIg-FISH, IGH rearrangement, multiple myeloma

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 6. 2008 10:10, RNDr. Henrieta Grešliková

Anotace

ORIG CZ

V originále

Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Median of time to progression (TTP) was 17.5 (0.4-41.4) months. Median of overall survival (OS) was 22.9 (0.4-48.5) months. The aberration of the chromosome 13 was found in 58% (40/69), IGH rearrangements in 57% (37/65), t(11;14) in 36% (13/37), t(4;14) in 33% (12/37) and deletion of 17p13 in 50% (23/46) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. Higher Ca concentration (p = 0.042) was found in patient with t(11;14). We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18.5 vs.21.9 months; p=0.287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration. This analysis will be extended for all centres of CMG 2002.

Česky

Práce pojednává o význame chromozomových zmien a ich vztahu k štandardným prognostickým faktorom u pacientov s mnohopočetným myelomem léčených konvenčnou chemoterapiou a následnou autológnou transplantáciou.

Návaznosti

NR8183, projekt VaV

Název: Molekulárně-cytogenetická analýza značených plazmatických buněk a prognostický význam klonálních chromosomových aberací u mnohočetného myelomu

Citovat

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR, Zdeněk ADAM, Andrea KŘIVANOVÁ, Marta KREJČÍ, Jana SMEJKALOVÁ a Roman HÁJEK. ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In Hematologica/The Hematology Journal. Volume 92, supplement no.1. Pavia, Italy: Ferrata-Storti Foundation, 2007, s. 497-497. ISSN 0390-6078.

@inproceedings{727209,
   author = {Grešliková, Henrieta and Filková, Hana and Kuglík, Petr and Oltová, Alexandra and Pour, Luděk and Adam, Zdeněk and Křivanová, Andrea and Krejčí, Marta and Smejkalová, Jana and Hájek, Roman},
   address = {Pavia, Italy},
   booktitle = {Hematologica/The Hematology Journal},
   edition = {Volume 92, supplement no.1},
   keywords = {Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion},
   language = {eng},
   location = {Pavia, Italy},
   pages = {497-497},
   publisher = {Ferrata-Storti Foundation},
   title = {ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION},
   year = {2007}
}

TY  - JOUR
ID  - 727209
AU  - Grešliková, Henrieta - Filková, Hana - Kuglík, Petr - Oltová, Alexandra - Pour, Luděk - Adam, Zdeněk - Křivanová, Andrea - Krejčí, Marta - Smejkalová, Jana - Hájek, Roman
PY  - 2007
TI  - ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
PB  - Ferrata-Storti Foundation
CY  - Pavia, Italy
KW  - Multiple Myeloma;cIg-FISH;13q deletion;IGH rearrangement;17p13 deletion
N2  - Background Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. Aims To determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17.5 months, median age 57 years (39-67), DS stadium: stage I 7.1%, II 24.3%, III 68.6%; A/B - 84.3%/15.7%. Results Overall response (OR) rate after AT was 78.5% including 13% CR, 27% VGPR and 38.5% PR. Median of time to progression (TTP) was 17.5 (0.4-41.4) months. Median of overall survival (OS) was 22.9 (0.4-48.5) months. The aberration of the chromosome 13 was found in 58% (40/69), IGH rearrangements in 57% (37/65), t(11;14) in 36% (13/37), t(4;14) in 33% (12/37) and deletion of 17p13 in 50% (23/46) pts. We have correlated standard prognostic factors (MIG, LD, B2M, Hb, CRP, Ca, albumin), TTP, progression free survival (PFS), duration of response (DOR) and OS with the occurrence of the mentioned aberrations. Higher CRP, lower albumin and lower Ca concentrations were detected in patients with aberration of chromosome 13. Higher Ca concentration (p = 0.042) was found in patient with t(11;14). We have observed trend for shorter TTP in patients with deletion of 17p13 and then in pts without this deletion (18.5 vs.21.9 months; p=0.287). As for this aberration we have found no significant difference when compared incidence of each chromosomal aberration for TTP, DOR, PFS and OS. Summary/Conclusion We have analysed data of the homogenous group of patients undergoing autologous transplantation in the CMG trial of Czech Myeloma Group. Based on the results we conclude that patients with deletion of 13q14 have higher CRP, lower albumin and lower Ca concentration. This analysis will be extended for all centres of CMG 2002.
ER  -

GREŠLIKOVÁ, Henrieta, Hana FILKOVÁ, Petr KUGLÍK, Alexandra OLTOVÁ, Luděk POUR, Zdeněk ADAM, Andrea KŘIVANOVÁ, Marta KREJČÍ, Jana SMEJKALOVÁ a Roman HÁJEK. ASSOCIATION BETWEEN CHROMOSOMAL CHANGES AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION. In \textit{Hematologica/The Hematology Journal}. Volume 92, supplement no.1. Pavia, Italy: Ferrata-Storti Foundation, 2007, s.~497-497. ISSN~0390-6078.

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