ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED
CASE-CONTROL STUDY

a 2007

ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ a Julie BIENERTOVÁ VAŠKŮ

Základní údaje

Originální název

ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY

Název česky

Endometriální karcinom a cholecystektomie - populační case-control studie

Autoři

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ a Julie BIENERTOVÁ VAŠKŮ

Vydání

Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO), 2007

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Endometrial cancer; cholecystectomy; obesity; population study

Štítky

cholecystectomy, endometrial cancer, obesity, population study

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 4. 2012 11:34, Mgr. Michal Petr

Anotace

ORIG CZ

V originále

Introduction: Estrogen, both endogenous and exogenous, is generally recognized as a potential risk factor in endometrial cancer. It is also known that postmenopausal estrogen use is involved in endometrial cancer pathophysiology. In this case control study, we analyzed whether having gallstones or a cholecystectomy, which are much more common in obese women or those who use exogenous estrogen, might be associated with endometrial cancer risk. Material, methods: A total of 470 patients with endometrial cancer were enrolled in the study along with 369 control women of comparable age without history of malignancy. Participants completed a structured questionnaire focused mainly on the reproductive history of the patients, history of cholecystectomy or gallstones and postmenopausal replacement therapy. Information on tumor staging or grading were obtained from the medical records along with cholesterol plasma levels. BMI at the time of diagnosis was calculated. Results: No case control differences in cholecystectomy frequency were observed between the endometrial cancer patients and controls. Endometrial cancer was found to be associated with obesity, age and low parity. Age of menarche was significantly associated to estrogen receptor presence in tumor mass (p=0.03), Discussion: As lack of association was observed, it might be concluded that cholecystectomy or gallstones do not represent a significant risk factor for endometrial cancer development in the Czech population.

Česky

V této populační case-control studii jsme nepozorovali statisticky významnou souvislost mezi výskytem endometriálního karcinomu a anamnézou cholecystektomie. Anamnestický údaj o cholecystektomii se tak z hlediska možného zvýšeného rizika endometriálního karcinomu nejeví jako významný.

Citovat

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ a Julie BIENERTOVÁ VAŠKŮ. ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY. In Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO). 2007.

@proceedings{743273,
   author = {Chovanec, Josef and Dostálová, Zuzana and Bienertová Vašků, Julie},
   booktitle = {Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO)},
   keywords = {Endometrial cancer; cholecystectomy; obesity; population study},
   language = {eng},
   title = {ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY},
   year = {2007}
}

TY  - CONF
ID  - 743273
AU  - Chovanec, Josef - Dostálová, Zuzana - Bienertová Vašků, Julie
PY  - 2007
TI  - ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY
KW  - Endometrial cancer
KW  - cholecystectomy
KW  - obesity
KW  - population study
N2  - Introduction: Estrogen, both endogenous and exogenous, is generally recognized as a potential risk factor in endometrial cancer. It is also known that postmenopausal estrogen use is involved in endometrial cancer pathophysiology. In this case control study, we analyzed whether having gallstones or a cholecystectomy, which are much more common in obese women or those who use exogenous estrogen, might be associated with endometrial cancer risk. Material, methods: A total of 470 patients with endometrial cancer were enrolled in the study along with 369 control women of comparable age without history of malignancy. Participants completed a structured questionnaire focused mainly on the reproductive history of the patients, history of cholecystectomy or gallstones and postmenopausal replacement therapy. Information on tumor staging or grading were obtained from the medical records along with cholesterol plasma levels. BMI at the time of diagnosis was calculated. Results: No case control differences in cholecystectomy frequency were observed between the endometrial cancer patients and controls. Endometrial cancer was found to be associated with obesity, age and low parity. Age of menarche was significantly associated to estrogen receptor presence in tumor mass (p=0.03), Discussion: As lack of association was observed, it might be concluded that cholecystectomy or gallstones do not represent a significant risk factor for endometrial cancer development in the Czech population.
ER  -

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ a Julie BIENERTOVÁ VAŠKŮ. ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY. In \textit{Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO)}. 2007.

Podrobný výpis o publikaci