ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED
CASE-CONTROL STUDY

a 2007

ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ and Julie BIENERTOVÁ VAŠKŮ

Basic information

Original name

ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY

Name in Czech

Endometriální karcinom a cholecystektomie - populační case-control studie

Authors

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ and Julie BIENERTOVÁ VAŠKŮ

Edition

Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO), 2007

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords in English

Endometrial cancer; cholecystectomy; obesity; population study

Abstract

ORIG CZ

V originále

Introduction: Estrogen, both endogenous and exogenous, is generally recognized as a potential risk factor in endometrial cancer. It is also known that postmenopausal estrogen use is involved in endometrial cancer pathophysiology. In this case control study, we analyzed whether having gallstones or a cholecystectomy, which are much more common in obese women or those who use exogenous estrogen, might be associated with endometrial cancer risk. Material, methods: A total of 470 patients with endometrial cancer were enrolled in the study along with 369 control women of comparable age without history of malignancy. Participants completed a structured questionnaire focused mainly on the reproductive history of the patients, history of cholecystectomy or gallstones and postmenopausal replacement therapy. Information on tumor staging or grading were obtained from the medical records along with cholesterol plasma levels. BMI at the time of diagnosis was calculated. Results: No case control differences in cholecystectomy frequency were observed between the endometrial cancer patients and controls. Endometrial cancer was found to be associated with obesity, age and low parity. Age of menarche was significantly associated to estrogen receptor presence in tumor mass (p=0.03), Discussion: As lack of association was observed, it might be concluded that cholecystectomy or gallstones do not represent a significant risk factor for endometrial cancer development in the Czech population.

In Czech

V této populační case-control studii jsme nepozorovali statisticky významnou souvislost mezi výskytem endometriálního karcinomu a anamnézou cholecystektomie. Anamnestický údaj o cholecystektomii se tak z hlediska možného zvýšeného rizika endometriálního karcinomu nejeví jako významný.

Citovat

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ and Julie BIENERTOVÁ VAŠKŮ. ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY. In Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO). 2007.

@proceedings{743273,
   author = {Chovanec, Josef and Dostálová, Zuzana and Bienertová Vašků, Julie},
   booktitle = {Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO)},
   keywords = {Endometrial cancer; cholecystectomy; obesity; population study},
   language = {eng},
   title = {ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY},
   year = {2007}
}

TY  - CONF
ID  - 743273
AU  - Chovanec, Josef - Dostálová, Zuzana - Bienertová Vašků, Julie
PY  - 2007
TI  - ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY
KW  - Endometrial cancer
KW  - cholecystectomy
KW  - obesity
KW  - population study
N2  - Introduction: Estrogen, both endogenous and exogenous, is generally recognized as a potential risk factor in endometrial cancer. It is also known that postmenopausal estrogen use is involved in endometrial cancer pathophysiology. In this case control study, we analyzed whether having gallstones or a cholecystectomy, which are much more common in obese women or those who use exogenous estrogen, might be associated with endometrial cancer risk. Material, methods: A total of 470 patients with endometrial cancer were enrolled in the study along with 369 control women of comparable age without history of malignancy. Participants completed a structured questionnaire focused mainly on the reproductive history of the patients, history of cholecystectomy or gallstones and postmenopausal replacement therapy. Information on tumor staging or grading were obtained from the medical records along with cholesterol plasma levels. BMI at the time of diagnosis was calculated. Results: No case control differences in cholecystectomy frequency were observed between the endometrial cancer patients and controls. Endometrial cancer was found to be associated with obesity, age and low parity. Age of menarche was significantly associated to estrogen receptor presence in tumor mass (p=0.03), Discussion: As lack of association was observed, it might be concluded that cholecystectomy or gallstones do not represent a significant risk factor for endometrial cancer development in the Czech population.
ER  -

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ and Julie BIENERTOVÁ VAŠKŮ. ENDOMETRIAL CANCER AND CHOLECYSTECTOMY: A POPULATION-BASED CASE-CONTROL STUDY. In \textit{Proceedings of the 15th International Meeting of the European Society of Gynaecological Oncology (ESGO)}. 2007.

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