BRYJA, Vítězslav, Lukáš ČAJÁNEK, A. GRAHN a G. SCHULTE. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiologica. Oxford: Blackwell Publishing, 2007, roč. 190, č. 1, s. 53-59. ISSN 1748-1708. |
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@article{745009, author = {Bryja, Vítězslav and Čajánek, Lukáš and Grahn, A. and Schulte, G.}, article_location = {Oxford}, article_number = {1}, keywords = {beta-catenin; clathrin-mediated endocytosis; desensitization}, language = {eng}, issn = {1748-1708}, journal = {Acta Physiologica}, title = {Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation}, volume = {190}, year = {2007} }
TY - JOUR ID - 745009 AU - Bryja, Vítězslav - Čajánek, Lukáš - Grahn, A. - Schulte, G. PY - 2007 TI - Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation JF - Acta Physiologica VL - 190 IS - 1 SP - 53-59 EP - 53-59 PB - Blackwell Publishing SN - 17481708 KW - beta-catenin KW - clathrin-mediated endocytosis KW - desensitization N2 - We investigated the effects of endocytosis inhibition on Frizzled4-green fluorescent protein (FZD4-GFP) localization, dishevelled levels and Wnt-3a signalling to beta -catenin. Hyperosmotic sucrose and K+ depletion increased the membrane localization of FZD4-GFP, and in parallel triggered fast (1–2 h) and almost complete (approx. 95%) degradation of endogenous dishevelled, which further prevented canonical signalling by Wnt-3a to beta-catenin. The data provide evidence for a molecular mechanism that could be a basis for a novel negative feedback loop within the Wnt/Frizzled pathway depending on dishevelled degradation. ER -
BRYJA, Vítězslav, Lukáš ČAJÁNEK, A. GRAHN a G. SCHULTE. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. \textit{Acta Physiologica}. Oxford: Blackwell Publishing, 2007, roč.~190, č.~1, s.~53-59. ISSN~1748-1708.
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