PŘIKRYL, Radovan, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Hana KUČEROVÁ. Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia. European Psychiatry. Elsevier, 2007, roč. 2007, č. 22, s. 499-504, 5 s. ISSN 0924-9338. |
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@article{745068, author = {Přikryl, Radovan and Češková, Eva and Kašpárek, Tomáš and Kučerová, Hana}, article_number = {22}, keywords = {soft signs; first episode schizophrenia; outcome}, language = {eng}, issn = {0924-9338}, journal = {European Psychiatry}, title = {Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia}, volume = {2007}, year = {2007} }
TY - JOUR ID - 745068 AU - Přikryl, Radovan - Češková, Eva - Kašpárek, Tomáš - Kučerová, Hana PY - 2007 TI - Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia JF - European Psychiatry VL - 2007 IS - 22 SP - 499-504 EP - 499-504 PB - Elsevier SN - 09249338 KW - soft signs KW - first episode schizophrenia KW - outcome N2 - Objective: (a) to find a relationship between the severity of neurological soft signs at the beginning of the disease and at the one-year follow-up of schizophrenia, and (b) to investigate temporal stability of neurological soft signs within one year from the first episode schizophrenia. Methods: The trial included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a one-year follow-up. The patients were divided into remitters and non-remitters according to their psychic state assessed at the one year follow-up, using the Positive and Negative Syndrome Scale (PANSS). Results: A trend of a lower score for the NES item "others" in late remitters versus non-remitters during was found during index hospitalization. At the one-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within one year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within one year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. Conclusion: Our study of the population of patients with first episode schizophrenia is in accord with the findings of those existing studies which had found a connection between neurological soft signs, treatment reactivity and outcome. This association may characterize a subgroup of patients with a poor illness course and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia. ER -
PŘIKRYL, Radovan, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Hana KUČEROVÁ. Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia. \textit{European Psychiatry}. Elsevier, 2007, roč.~2007, č.~22, s.~499-504, 5 s. ISSN~0924-9338.
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