2007
Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia
PŘIKRYL, Radovan, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK a Hana KUČEROVÁZákladní údaje
Originální název
Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia
Název česky
Neurologické měkké příznaky a jejich vztah k jednoleté prognóze u první epizody schizofrenie
Autoři
PŘIKRYL, Radovan (203 Česká republika, garant), Eva ČEŠKOVÁ (203 Česká republika), Tomáš KAŠPÁREK (203 Česká republika) a Hana KUČEROVÁ (203 Česká republika)
Vydání
European Psychiatry, Elsevier, 2007, 0924-9338
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.875
Kód RIV
RIV/00216224:14110/07:00023059
Organizační jednotka
Lékařská fakulta
UT WoS
000251119500003
Klíčová slova anglicky
soft signs; first episode schizophrenia; outcome
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 17. 6. 2009 11:06, prof. MUDr. Eva Češková, CSc.
V originále
Objective: (a) to find a relationship between the severity of neurological soft signs at the beginning of the disease and at the one-year follow-up of schizophrenia, and (b) to investigate temporal stability of neurological soft signs within one year from the first episode schizophrenia. Methods: The trial included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a one-year follow-up. The patients were divided into remitters and non-remitters according to their psychic state assessed at the one year follow-up, using the Positive and Negative Syndrome Scale (PANSS). Results: A trend of a lower score for the NES item "others" in late remitters versus non-remitters during was found during index hospitalization. At the one-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within one year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within one year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. Conclusion: Our study of the population of patients with first episode schizophrenia is in accord with the findings of those existing studies which had found a connection between neurological soft signs, treatment reactivity and outcome. This association may characterize a subgroup of patients with a poor illness course and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.
Česky
Neurologické měkké příznaky u pacientů s první epizodou schizofrenie souvisí s jednoletou prognózou onemocnění. Jejich vyšší intenzita koreluje s horším průběhm schizofrenie.
Návaznosti
| MSM0021622404, záměr |
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