GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA and Marek SVOBODA. Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes. In Proceedings of the American Association for Cancer Research. 2007. vyd. Columbia, USA: American Association for Cancer Reasearch, Inc., Philadelphia, USA, 2007. p. 133-133, 1 pp. ISSN 0197-016X.
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Basic information
Original name Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes
Name in Czech Nádory tlustého střeva a možný význam populace T-buněk, včetně FOXP3-pozitivních lymfocytů
Authors GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA and Marek SVOBODA.
Edition 2007. vyd. Columbia, USA, Proceedings of the American Association for Cancer Research, p. 133-133, 1 pp. 2007.
Publisher American Association for Cancer Reasearch, Inc., Philadelphia, USA
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
ISSN 0197-016X
Keywords in English colon carcinoma;T-cell lymphocytes;FOXP3
Tags colon carcinoma, FOXP3, T-cell lymphocytes
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Marek Svoboda, Ph.D., učo 19402. Changed: 19/12/2007 01:16.
Abstract
Tumor-infiltrating lymphocytes (TIL) of colon carcinoma (CC) include also cytotoxic T-cells that are generally considered as prognostically favourable because of their ability to exert anti-tumor immunity. As progression of CC occurs, the question arises whether the CC microenvironment may have some suppressive capabilities. We were interested if a recently discovered subgroup of T-cells, namely regulatory T-cells (TREG, CD4+ CD25+ FOXP3+), which are able to functionally suppress immune responses and are supposed to lead to tumor progression, makes part of TIL of CC. We used immunohistochemical staining to detect lymphocytes co-expressing CD4+ and FOXP3+ in 44 cases of CC primary tumors, using formalin-fixed and paraffin-embedded sections, and commercially available monoclonal antibodies. We were first indeed to show the occurence of FOXP3+ TREG lymphocytes in CC. What we found interesting in futher studies was the localization of FOXP3+ cells. We observed them in stroma, within the epitelium, but above all they formed invasive fragment between cancer and non-cancer tissue. This localization is very suspicious to play a role in local immune system, although to explain this fact there are futher experiments undergoing in our laboratory. Investigations, in fact, are in progress on: (i) differences in TREG distribution between left/right side-localized CC, (ii) differences in TREG distribution among CC in clinical stage I-IV, (iii) TREG behaviour in cases asssociated with microsatelite instability, which is known to have more favourable clinical outcome. This project is supported by Internal Grant Agency, Ministry of Health, Czech Republic. No.: NR/9076-4.
Abstract (in Czech)
Publikace je pouze v aglickém jazyce.
Links
NR9076, research and development projectName: Genomické profilování v predikci odpovědi na chemoradioterapii u pacientů s lokálně pokročilým karcinomem konečníku
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