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@proceedings{746366,
author = {Veselská, Renata and Loja, Tomáš and Chlapek, Petr and Hermanová, Markéta and Zavřelová, Iva and Zitterbart, Karel and Štěrba, Jaroslav},
booktitle = {Proceedings - European Biomarkers Summit and Proteomics Europe 2007},
keywords = {nestin; intermediate filaments; glioblastoma multiforme; osteosarcoma; neuroblastoma; medulloblastoma; malignant fibrose histiocytoma},
language = {eng},
title = {Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines},
year = {2007}
}
TY - CONF
ID - 746366
AU - Veselská, Renata - Loja, Tomáš - Chlapek, Petr - Hermanová, Markéta - Zavřelová, Iva - Zitterbart, Karel - Štěrba, Jaroslav
PY - 2007
TI - Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
KW - nestin
KW - intermediate filaments
KW - glioblastoma multiforme
KW - osteosarcoma
KW - neuroblastoma
KW - medulloblastoma
KW - malignant fibrose histiocytoma
N2 - Nestin (intermediate filament class VI protein) is expressed in proliferating neuroepithelium during the development of mammalian CNS as well as in human and rodent neural stem cells and cell lines. In the adult CNS, nestin is detectable only in stem cells of the subventricular zone and partly in the choroid plexus. Our study was aimed at the nestin expression in cell lines derived from different types of solid tumors both in children and adults. Using immunodetection methods, nestin expression has been shown in tissue sections and cell lines derived from neuroectodermal tumors (glioblastoma multiforme, neuroblastoma), as well as from malignant fibrose histiocytoma and osteosarcoma. We also focused on the subcellular localization of nestin in the cell lines as described above. Our results brought the direct evidence of the nestin occurrence in cell nucleus in cell lines derived from neuroblastoma and glioblastoma multiforme. These results suggest that localization of nestin in the transformed cells is not limited to the cytoplasm only and this protein may play an important role either in the chromatin organization or in the regulation of gene expression.
ER -
VESELSKÁ, Renata, Tomáš LOJA, Petr CHLAPEK, Markéta HERMANOVÁ, Iva ZAVŘELOVÁ, Karel ZITTERBART and Jaroslav ŠTĚRBA. Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines. In \textit{Proceedings - European Biomarkers Summit and Proteomics Europe 2007}. 2007.
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