Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

ŠVESTKA, Jaromír, Oldřich SYNEK a Jana TOMANOVÁ. Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2007, roč. 28, č. 6, s. 881-888. ISSN 0172-780X.

Základní údaje

Originální název

Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

Název česky

Rozdílnost efektu antipsychotik druhé generace na prolaktinémii. Šestitýdenní otevřená studie u pacientů ženského pohlaví

Název anglicky

Differences in the effect of second-generation antipsychotics on prolactinaemia: Six weeks open-label trial in female in-patients

Autoři

ŠVESTKA, Jaromír, Oldřich SYNEK a Jana TOMANOVÁ

Vydání

Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2007, 0172-780X

---

Další údaje

Jazyk

čeština

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.443

Organizační jednotka

Lékařská fakulta

UT WoS

000252066300027

Klíčová slova anglicky

second-generation antipsychotics; hyperprolactinaemia; prevalence; dynamics of change; correlations with other parameters

Štítky

correlations with other parameters, dynamics of change, hyperprolactinaemia, prevalence, second-generation antipsychotics

Příznaky

Mezinárodní význam, Recenzováno

---

Anotace

V originále

The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.

Anglicky

The main objective was to evaluate the effect of five second-generation antipsychotics (amisulpride, quetiapine, olanzapine, risperidone, and zotepine) on prolactinaemia during 6 week therapy in 433 female in-patients with mainly schizophrenic disorders. Secondary objectives included identification of dynamics of change in serum prolactin levels and correlations of changes of prolactinaemia with some demographic and clinical parameters. The trial was a prospective, open-label, single-center one with a flexible dosing of SGAs. The therapeutic effect of SGAs was assessed by a change of scores of CGI-S and CGI-I scales from a baseline to the endpoint. Blood samples were taken in the morning under fasting condition.