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@proceedings{747094, author = {Šmardová, Lenka and Huser, Martin and Král, Zdeněk and Crha, Igor}, booktitle = {Haematologica/The Hematology Journal}, keywords = {Hodgkins lymphoma; gonadoliberine analogues; premature ovarian failure}, language = {eng}, title = {Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration}, year = {2007} }
TY - CONF ID - 747094 AU - Šmardová, Lenka - Huser, Martin - Král, Zdeněk - Crha, Igor PY - 2007 TI - Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration KW - Hodgkins lymphoma KW - gonadoliberine analogues KW - premature ovarian failure N2 - Background: The risk of POF onset depends mainly on womens age and foliculogenesis status in ovary, chemotherapy (CT) regimen used and cumulative dose of single cytotoxic agents. Aims: Aim of this prospective case-control study is evaluation of gonadoliberine analogues (GnRHa) administration to patients with Hodgkins lymphoma (HL) during chemotherapy and prevention of ovarian damage depending upon CT dose and regimen. Methods: Study group consists of 72 patients in fertile age with HL by curative CT together with GnRHa administration according standardized protocol. Group A received ABVD, group B baseline BEACOPP and ABVD in combination, group C dose escalated BEACOPP regimen. Results: In study group with GnRHa administration during CT there was statistical significantly less cases with POF (38.2 %) in 6 month after end of CT than in control group (73.4 %). After 12 month POF was detected in 48.8 % of cases versus 69.3 % in control group. Summary: Study proved significant reduction of ovarian failure risk in women with HL treated with less aggressive CT regimens. ER -
ŠMARDOVÁ, Lenka, Martin HUSER, Zdeněk KRÁL a Igor CRHA. Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration. In \textit{Haematologica/The Hematology Journal}. 2007. ISSN~0390-6078.
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