Malignant fibrous histiocytoma of the parotid gland

J 2007

Malignant fibrous histiocytoma of the parotid gland

MAČÁK, Jirka, Jana ŠMARDOVÁ, Iva ZAVŘELOVÁ, Vladimíra VRANOVÁ, Petr KUGLÍK et. al.

Základní údaje

Originální název

Malignant fibrous histiocytoma of the parotid gland

Název česky

Maligní fibrózní histiocytom příušní slinné žlázy

Autoři

MAČÁK, Jirka, Jana ŠMARDOVÁ, Iva ZAVŘELOVÁ, Vladimíra VRANOVÁ a Petr KUGLÍK

Vydání

Čes.-slov. Patol. Praha, Olympia a.s. 2007, 1210-7875

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

malignant fibrous histiocytoma; parotid gland; immunohistochemistry; molecular biology methods, p53 gene, comparative genomic hybridization

Štítky

Immunohistochemistry, malignant fibrous histiocytoma, parotid gland

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 1. 2008 06:59, prof. MUDr. Jirka Mačák, CSc.

Anotace

V originále

We described a rare malignant fibrous histiocytoma of the parotid gland (MFH) in a 63-year-old woman. During six months tumoursize became 10 cm in diameter with skon ulceration. The tumour was examined morphologically, by immunohistochemistry and molecular biology methods - FASAY and CGH. The histology revealed a storiform-pleomorphic type of MFH with high mitotic rate. The FASAY method identified a non-mutated p53 gene. The chromosomal changes were identified by the CGH method and 6 cytogenetic changes were found in the tumour cells (deletions at 8p12-p22, 13q32-qter, 14q24-qter, and gains of chromosomal material at 5p, 8q12-q23, and Xq25-qter). The patient died shortly after the beginning of chemotherapy. Autopsy revealed brain and cerebellar haemorrhage. No other tumour foci were proved. In view of short course of disease we lack the data about the influence of the non-mutated p53 gene on the prognosis and therapy.

Citovat

MAČÁK, Jirka, Jana ŠMARDOVÁ, Iva ZAVŘELOVÁ, Vladimíra VRANOVÁ a Petr KUGLÍK. Malignant fibrous histiocytoma of the parotid gland. Čes.-slov. Patol. Praha: Olympia a.s., 2007, roč. 43, č. 4, s. 148-152. ISSN 1210-7875.

@article{748092,
   author = {Mačák, Jirka and Šmardová, Jana and Zavřelová, Iva and Vranová, Vladimíra and Kuglík, Petr and Šmardová, Jana and Zavřelová, Iva and Vranová, Vladimíra and Kuglík, Petr},
   article_location = {Praha},
   article_number = {4},
   keywords = {malignant fibrous histiocytoma; parotid gland; immunohistochemistry; molecular biology methods, p53 gene, comparative genomic hybridization},
   language = {eng},
   issn = {1210-7875},
   journal = {Čes.-slov. Patol.},
   title = {Malignant fibrous histiocytoma of the parotid gland},
   url = {http://www.clsjep.cz},
   volume = {43},
   year = {2007}
}

TY  - JOUR
ID  - 748092
AU  - Mačák, Jirka - Šmardová, Jana - Zavřelová, Iva - Vranová, Vladimíra - Kuglík, Petr - Šmardová, Jana - Zavřelová, Iva - Vranová, Vladimíra - Kuglík, Petr
PY  - 2007
TI  - Malignant fibrous histiocytoma of the parotid gland
JF  - Čes.-slov. Patol.
VL  - 43
IS  - 4
SP  - 148-152
EP  - 148-152
PB  - Olympia a.s.
SN  - 12107875
KW  - malignant fibrous histiocytoma
KW  - parotid gland
KW  - immunohistochemistry
KW  - molecular biology methods, p53 gene, comparative genomic hybridization
UR  - http://www.clsjep.cz
N2  - We described a rare malignant fibrous histiocytoma of the parotid gland (MFH) in a 63-year-old woman. During six months tumoursize became 10 cm in diameter with skon ulceration. The tumour was examined morphologically, by immunohistochemistry and molecular biology methods - FASAY and CGH. The histology revealed a storiform-pleomorphic type of MFH with high mitotic rate. The FASAY method identified a non-mutated p53 gene. The chromosomal changes were identified by the CGH method and 6 cytogenetic changes were found in the tumour cells (deletions at 8p12-p22, 13q32-qter, 14q24-qter, and gains of chromosomal material at 5p, 8q12-q23, and Xq25-qter). The patient died shortly after the beginning of chemotherapy. Autopsy revealed brain and cerebellar haemorrhage. No other tumour foci were proved. In view of short course of disease we lack the data about the influence of the non-mutated p53 gene on the prognosis and therapy.
ER  -

MAČÁK, Jirka, Jana ŠMARDOVÁ, Iva ZAVŘELOVÁ, Vladimíra VRANOVÁ a Petr KUGLÍK. Malignant fibrous histiocytoma of the parotid gland. \textit{Čes.-slov. Patol.}. Praha: Olympia a.s., 2007, roč.~43, č.~4, s.~148-152. ISSN~1210-7875.

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