KŘÍŽ, Vítězslav, Jaroslav MAREŠ, Parri WENTZEL, Nina FUNA, Gabriela ČALOUNOVÁ, Xiao-Qun ZHANG, Karin FORSBERG-NILSSON, Maud FORSBERG a Michael WELSH. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Developmental dynamics. United States: Wiley-Liss, 2007, roč. 236, č. 9, s. 2485-2492. ISSN 1058-8388. Dostupné z: https://dx.doi.org/10.1002/dvdy.21257. |
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@article{748133, author = {Kříž, Vítězslav and Mareš, Jaroslav and Wentzel, Parri and Funa, Nina and Čalounová, Gabriela and Zhang, XiaoandQun and ForsbergandNilsson, Karin and Forsberg, Maud and Welsh, Michael}, article_location = {United States}, article_number = {9}, doi = {http://dx.doi.org/10.1002/dvdy.21257}, keywords = {SHB; knockout; ovulation; malformations; viability in utero; transmission ratio distortion}, language = {eng}, issn = {1058-8388}, journal = {Developmental dynamics}, title = {Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.}, volume = {236}, year = {2007} }
TY - JOUR ID - 748133 AU - Kříž, Vítězslav - Mareš, Jaroslav - Wentzel, Parri - Funa, Nina - Čalounová, Gabriela - Zhang, Xiao-Qun - Forsberg-Nilsson, Karin - Forsberg, Maud - Welsh, Michael PY - 2007 TI - Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. JF - Developmental dynamics VL - 236 IS - 9 SP - 2485-2492 EP - 2485-2492 PB - Wiley-Liss SN - 10588388 KW - SHB KW - knockout KW - ovulation KW - malformations KW - viability in utero KW - transmission ratio distortion N2 - SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development. ER -
KŘÍŽ, Vítězslav, Jaroslav MAREŠ, Parri WENTZEL, Nina FUNA, Gabriela ČALOUNOVÁ, Xiao-Qun ZHANG, Karin FORSBERG-NILSSON, Maud FORSBERG a Michael WELSH. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. \textit{Developmental dynamics}. United States: Wiley-Liss, 2007, roč.~236, č.~9, s.~2485-2492. ISSN~1058-8388. Dostupné z: https://dx.doi.org/10.1002/dvdy.21257.
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