KŘÍŽ, Vítězslav, Jaroslav MAREŠ, Parri WENTZEL, Nina FUNA, Gabriela ČALOUNOVÁ, Xiao-Qun ZHANG, Karin FORSBERG-NILSSON, Maud FORSBERG and Michael WELSH. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Developmental dynamics. United States: Wiley-Liss, 2007, vol. 236, No 9, p. 2485-2492. ISSN 1058-8388. Available from: https://dx.doi.org/10.1002/dvdy.21257.
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Basic information
Original name Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.
Name in Czech Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero.
Authors KŘÍŽ, Vítězslav (203 Czech Republic, guarantor, belonging to the institution), Jaroslav MAREŠ (203 Czech Republic), Parri WENTZEL (752 Sweden), Nina FUNA (752 Sweden), Gabriela ČALOUNOVÁ (203 Czech Republic), Xiao-Qun ZHANG (156 China), Karin FORSBERG-NILSSON (752 Sweden), Maud FORSBERG (752 Sweden) and Michael WELSH (840 United States of America).
Edition Developmental dynamics, United States, Wiley-Liss, 2007, 1058-8388.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.084
RIV identification code RIV/00216224:14310/07:00050891
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/dvdy.21257
UT WoS 000249539700012
Keywords in English SHB; knockout; ovulation; malformations; viability in utero; transmission ratio distortion
Tags AKR, knockout, malformations, ovulation, rivok, SHB, transmission ratio distortion, viability in utero
Tags International impact, Reviewed
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 13/4/2012 12:07.
Abstract
SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.
Abstract (in Czech)
SHB is an Src homology 2 domain-containing adapter protein that has been found to be involved in numerous cellular responses. We have generated an Shb knockout mouse. No Shb-/- pups or embryos were obtained on the C57Bl6 background, indicating an early defect as a consequence of Shb- gene inactivation on this genetic background. Breeding heterozygotes for Shb gene inactivation (Shb+/-) on a mixed genetic background (FVB/C57Bl6/129Sv) reveals a distorted transmission ratio of the null allele with reduced numbers of Shb+/+ and Shb-/- animals, but increased number of Shb+/- animals. The Shb- allele is associated with various forms of malformations, explaining the relative reduction in the number of Shb-/- offspring. Shb-/- animals that were born were viable, fertile, and showed no obvious defects. However, Shb+/- female mice ovulated preferentially Shb- oocytes explaining the reduced frequency of Shb+/+ mice. Our study suggests a role of SHB during reproduction and development.
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