Detailed Information on Publication Record
2007
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
BERÁNEK, Michal, Petr KOLÁŘ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Anna VAŠKŮ et. al.Basic information
Original name
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Name in Czech
Genetic variation and plasma level of the basic fibroblast growth factor in proliferative diabetic retinopathy
Authors
BERÁNEK, Michal (203 Czech Republic, belonging to the institution), Petr KOLÁŘ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, guarantor, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)
Edition
Diabetes Res Clin Pract, Elsevier, 2007, 0168-8227
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.823
RIV identification code
RIV/00216224:14110/07:00020817
Organization unit
Faculty of Medicine
UT WoS
000253370200028
Keywords in English
basic fibroblast growth factor; proliferative diabetic retinopathy; haplotype; polymorphisms
Tags
International impact, Reviewed
Změněno: 29/10/2012 10:21, prof. MUDr. Petr Kolář, Ph.D.
V originále
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
In Czech
The basic fibroblast growth factor (bFGF) is considered to be one of the candidate genes in the processes of tumour growth and angiogenesis. The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. Allele, genotype and haplotype frequencies were determined in the association study comprising three groups of Caucasian subjects (n = 488) (diabetics with/PDR/and without retinopathy/non-PDR/and non-diabetics/ non-DM/) in order to identify genetic marker for PDR. The plasma level of the bFGF protein was analysed by ELISA method. Significantly higher frequencies of 754C allele of the new 754C/G polymorphisms was found between PDR and non-DM group (p=0.05, OR=1.38). The comparison of plasma level of the bFGF showed statistically significant difference among studied groups (p=0.001). The bFGF plasma level in PDR group was significantly higher than in the groups of non-PDR and non-DM (p=0.017, p=0.001, respectively) and was significantly higher for CC and GC genotypes of 754C/G polymorphism in PDR group (p=0.006). Increased plasma level of the bFGF confirmed the importance of this candidate gene in the formation of PDR. However, the regulatory mechanisms of the bFGF level need further examinations.
Links
| GP303/05/P523, research and development project |
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