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@proceedings{750763,
author = {Němec, Petr and Pávková Goldbergová, Monika and Chroust, Karel and Vašků, Anna and Souček, Miroslav},
keywords = {TNF; gene; rheumatoid; arthritis},
language = {eng},
title = {Polymorphism at position-308 of the TNF-alpha gene influences outcome of anti-TNF-alpha therapy in rheumatoid arthritis:preliminary results},
year = {2007}
}
TY - CONF
ID - 750763
AU - Němec, Petr - Pávková Goldbergová, Monika - Chroust, Karel - Vašků, Anna - Souček, Miroslav
PY - 2007
TI - Polymorphism at position-308 of the TNF-alpha gene influences outcome of anti-TNF-alpha therapy in rheumatoid arthritis:preliminary results
KW - TNF
KW - gene
KW - rheumatoid
KW - arthritis
N2 - Rheumatoid arthritis (RA) is a model of multigenic inflammatory disorder in which tumor necrosis factor-alpha (TNF-alpha) plays an important role. Genetic factors may be implicated in the susceptibility to disease initiation as well as in severity of disease course. Elevated levels of TNF-alpha in the plasma and synovial fluid from RA patients may be associated with polymorphisms in the promoter region of the TNF-alpha gene. The aim of this study was to elucidate putative association between the -308 G/A polymorphism in the promoter region of the TNF-alpha gene and susceptibility to onset and severity of RA. A total of 130 RA patients and a control group of 150 healthy subjects with similar age and sex distribution were available for the study. All patients fulfilled the American College of Rheumatology revised criteria for RA. RA patients had a disease duration of at least 2 years. Radiographs of both hands of all RA patients were scored with the Steinbrocker method. There were 15 patients of stage I (nonerosive form) of RA and 114 patients of stages II-IV (erosive form). To assess the RA patient's functional ability, the Health Assessment Questionnaire (HAQ) was used. The -308 G/A promoter polymorphism of the TNF-alpha gene was detected by polymerase chain reaction and restriction fragment length polymorphism analysis. No differences in genotype distribution and allelic frequences of -308 G/A TNF-alpha promoter polymorphism have been found between RA patients and the control group. Significant differences have been observed within the RA group divided according to the radiographic progression of disease based on the Steinbrocker radiographic score and functional ability (HAQ). These results suggest an association of the -308 G/A polymorphism of the TNF-alpha gene with the severity of RA.
ER -
NĚMEC, Petr, Monika PÁVKOVÁ GOLDBERGOVÁ, Karel CHROUST, Anna VAŠKŮ a Miroslav SOUČEK. \textit{Polymorphism at position-308 of the TNF-alpha gene influences outcome of anti-TNF-alpha therapy in rheumatoid arthritis:preliminary results}. 2007.
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