ŠPINAR, Jindřich, Ondřej LUDKA, Ladislav DUŠEK, Dorota SOBOTOVÁ and Lenka ŠPINAROVÁ. Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis. Kidney Blood Press res. 2007, vol. 30, No 5, p. 347-357. ISSN 1420-4096.
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Basic information
Original name Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis.
Name in Czech Neurohumoral activity, heart failure and prognosis in patients with end-stage renal disease treated by hemodialysis.
Authors ŠPINAR, Jindřich (203 Czech Republic, guarantor), Ondřej LUDKA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic), Dorota SOBOTOVÁ (203 Czech Republic) and Lenka ŠPINAROVÁ (203 Czech Republic).
Edition Kidney Blood Press res, 2007, 1420-4096.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Switzerland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.092
RIV identification code RIV/00216224:14110/07:00032953
Organization unit Faculty of Medicine
UT WoS 000249306000012
Keywords in English neurohumoral activity; heart failure; end-stage renal disease; hemodialysis
Tags end-stage renal disease, Heart failure, hemodialysis, neurohumoral activity
Changed by Changed by: prof. RNDr. Ladislav Dušek, Ph.D., učo 670. Changed: 1/4/2010 09:19.
Abstract
Background: Chronic renal failure treated by regular hemodialysis is frequently accompanied by chronic heart failure; the mortality of both is high. Aim: To evaluate the role of markers of neurohumoral activation for the prognosis of patients treated with regular dialysis. Patients: 99 patients with end-stage renal disease were followed up for 3 years. Methods: Clinical evaluation, echocardiography, biochemistry including NT-proBNP and big endothelin (Big-ET). Results: The incidence of heart failure was 97% and the 3-year mortality was 50%. The sensitivity of NT-proBNP and Big-ET level for the prediction of death was 0.712 and 0.824, respectively, and specificity 0.642 and 0.695, respectively. The cutoff points were NT-proBNP 6 2,000 pg/ml and Big-ET >= 1.55 pmol/l. Neither NT-proBNP nor Big-ET could be incorporated in the multivariate model for overall survival, which means that although both parameters significantly influenced overall survival as single risk factors, they were not effective in competition with the other significant predictors. Conclusion: Overall survival seems to be influenced namely by age, hemoglobin, left atrium diameter or pulmonary congestion class on chest X-ray, while probability of early risk was associated with Big-ET, history of diabetes mellitus, C-reactive protein, uric acid and hemoglobin. The only intersection of the models is hemoglobin as a thoroughly significant predictor. Copyright (c) 2007 S. Karger AG, Basel.
Abstract (in Czech)
Background: Chronic renal failure treated by regular hemodialysis is frequently accompanied by chronic heart failure; the mortality of both is high. Aim: To evaluate the role of markers of neurohumoral activation for the prognosis of patients treated with regular dialysis. Patients: 99 patients with end-stage renal disease were followed up for 3 years. Methods: Clinical evaluation, echocardiography, biochemistry including NT-proBNP and big endothelin (Big-ET). Results: The incidence of heart failure was 97% and the 3-year mortality was 50%. The sensitivity of NT-proBNP and Big-ET level for the prediction of death was 0.712 and 0.824, respectively, and specificity 0.642 and 0.695, respectively. The cutoff points were NT-proBNP 6 2,000 pg/ml and Big-ET >= 1.55 pmol/l. Neither NT-proBNP nor Big-ET could be incorporated in the multivariate model for overall survival, which means that although both parameters significantly influenced overall survival as single risk factors, they were not effective in competition with the other significant predictors. Conclusion: Overall survival seems to be influenced namely by age, hemoglobin, left atrium diameter or pulmonary congestion class on chest X-ray, while probability of early risk was associated with Big-ET, history of diabetes mellitus, C-reactive protein, uric acid and hemoglobin. The only intersection of the models is hemoglobin as a thoroughly significant predictor. Copyright (c) 2007 S. Karger AG, Basel.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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