KALA, Zdeněk, Jiří DOLINA, F. MAREK and L. IZAKOVIČOVÁ-HOLÁ. Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus. Journal of Hum Genetics. 2007, vol. 52, No 6, p. 526-534, 8 pp. ISSN 1434-5161.
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Basic information
Original name Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus
Name in Czech Polymorfismy glutathionS-transferázy M1,T1 a P1 u pacietnůs refluxní esofagitidou a Barretovým jícnem
Authors KALA, Zdeněk (203 Czech Republic, guarantor), Jiří DOLINA (203 Czech Republic), F. MAREK (203 Czech Republic) and L. IZAKOVIČOVÁ-HOLÁ (203 Czech Republic).
Edition Journal of Hum Genetics, 2007, 1434-5161.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.275
RIV identification code RIV/00216224:14110/07:00023553
Organization unit Faculty of Medicine
UT WoS 000247157100009
Keywords in English GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene
Tags gene, GERD, glutathione S-transferase, GSTs, polymorphism, reflux esophagitis
Changed by Changed by: Lenka Kovářová, učo 37199. Changed: 25/6/2008 11:47.
Abstract
Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus.
Abstract (in Czech)
Refluxní esofagitida a Barretův jícen jsou jedny z nejčastějších jícnových komplikací gastroezofageální refluxní choroby jícnu. Glutathion S transferázy hrají důležitou roli v buněčné ochraně proti oxidativnímu stresu a toxických chemikáliím. Přišli jsme s hypotézou, že polymorfismy v detoxifikačních genech mohou ovlivňovat vliv ke vzniku refluxní ezofagitidy a Barretova jícnu. Závěr: Přestože GSTM1 a GSTT1 neukázaly vztah k refluxní chorobě, gene GSTP1 by mohl být jedním z rizikových faktorů asociovaným s refluxní ezofagitidkou a Barretovým jícnem. Studie podpořena grantem NPV II-2B06060
Links
2B06060, research and development projectName: Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu (Acronym: NPVII11002)
Investor: Ministry of Education, Youth and Sports of the CR
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