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@article{751077, author = {Šrámek, Vladimír and Dadák, Lukáš and Šťouračová, M. and Šťetka, P. and Komolíková, Lucie and Kuklínek, Pavel}, article_location = {Praha}, article_number = {9}, keywords = {intensive care unit patients; immunoparalysis; Immodin}, language = {cze}, issn = {0042-773X}, journal = {Vnitřní lékařství}, title = {Immodin in the treatment of immunoparalysis in intensive care patients}, url = {http://www.unboundmedicine.com/medline/ebm/record/18019664/abstract/%5BImmodin_in_the_treatment_of_immunoparalysis_in_intensive_care_patients%5D}, volume = {53}, year = {2007} }
TY - JOUR ID - 751077 AU - Šrámek, Vladimír - Dadák, Lukáš - Šťouračová, M. - Šťetka, P. - Komolíková, Lucie - Kuklínek, Pavel PY - 2007 TI - Immodin in the treatment of immunoparalysis in intensive care patients JF - Vnitřní lékařství VL - 53 IS - 9 SP - 954-9 EP - 954-9 SN - 0042773X KW - intensive care unit patients KW - immunoparalysis KW - Immodin UR - http://www.unboundmedicine.com/medline/ebm/record/18019664/abstract/%5BImmodin_in_the_treatment_of_immunoparalysis_in_intensive_care_patients%5D N2 - OBJECTIVE: The objective of the study was to evaluate the effect of administration of the immunoregulating preparation Immodin (Sevapharma, CZ) to influence immunoparalysis in intensive care unit patients. METHOD: A double blind, randomised clinical study was designed for the above purpose. The patients in whom immunoparalysis was detected during monitoring (CD14+ HLA-DR+ < or = 40 %) were randomised for the administration of Immodin (IM) or placebo (PL); the treatment lasted for 5 days. 45 (25% of all monitored) patients - the men/women ratio being 29/16, 60 (54; 65) years of age - were enrolled in the study (of which 25 IM and 20 PL). RESULTS: The patients did not show differences in ICU mortality - 23 IM patients survived, 2 IM patients died; 15 PL patients survived and 5 PL patients died (p = 0.214). The time of ICU hospitalisation did not differ, either - 11.6 days for IM patients (8.2; 14.9), 12.6 days for PL patients (9.1; 16.1) (P = 0.659) - nor did the number of nosocomial infections - 4 out of 25 IM patients and 4 out of 20 PL patients (p = 0.776). No difference was observed between the patient groups during a 5 day intervention period in terms of SOFA score development (p = 0.954), SIRS days (p = 0.614), sepsis or severe sepsis (respectively p = 0.451 and p = 0.250). No difference was recorded in the trends of basic immunologic parameters, either (CD14+ HLA-DR+ - p = 0.460, production of TNFalpha - p = 0.802, IL-6 - p = 0.335 , IL-10 - p = 0.226). The trend of inflammation parameters was also identical (CRP - p = 0.673, PCT - p = 0.711 ). CONCLUSION: The effect of 5 day administration of Immodin to ICU patients with symptoms of immunoparalysis does not differ from that of placebo. ER -
ŠRÁMEK, Vladimír, Lukáš DADÁK, M. ŠŤOURAČOVÁ, P. ŠŤETKA, Lucie KOMOLÍKOVÁ a Pavel KUKLÍNEK. Immodin in the treatment of immunoparalysis in intensive care patients. \textit{Vnitřní lékařství}. Praha, 2007, roč.~53, č.~9, s.~954-9, 6 s. ISSN~0042-773X.
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