Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

GRACIA, Tannia, Klára HILSCHEROVÁ, P.D. JONES, J.L. NEWSTED, E.B. HIGLEY, X. ZHANG, Marcus HECKER, M. MURPHY, R.M.K. YU, P.K.S. LAM, R.S.S. WU and John P. GIESY. Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. Toxicology and applied pharmacology. 2007, vol. 225, No 2, p. 142-153. ISSN 0041-008X.

Basic information

• Original name: Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds
• Name in Czech: Modulace exprese steroidogenních enzymů a produkce hormonův buňkách H295R léčivy a dalšími látkami z životního prostředí
• Authors: GRACIA, Tannia (840 United States of America), Klára HILSCHEROVÁ (203 Czech Republic, guarantor), P.D. JONES (840 United States of America), J.L. NEWSTED (840 United States of America), E.B. HIGLEY (840 United States of America), X. ZHANG (344 Hong Kong), Marcus HECKER (276 Germany), M. MURPHY (840 United States of America), R.M.K. YU (344 Hong Kong), P.K.S. LAM (344 Hong Kong), R.S.S. WU (344 Hong Kong) and John P. GIESY (840 United States of America).
• Edition: Toxicology and applied pharmacology, 2007, 0041-008X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30304 Public and environmental health
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.846
• RIV identification code: RIV/00216224:14310/07:00023833
• Organization unit: Faculty of Science
• UT WoS: 000251332200003
• Keywords in English: steroidogenesis; in vitro; hormone production; pharmaceuticals; environmental pollutants; steroidogenic gene expression
• Tags: environmental pollutants, hormone production, in vitro, Pharmaceuticals, steroidogenesis, steroidogenic gene expression
• Tags: International impact, Reviewed

Abstract

The study has shown effects of some commonly used pharmaceuticals with a potential to enter the environment on the hormone production and expression of the key enzymes in steeroidogenesis, documenting thus side effects of these widely used drugs. The tests with binary mixtures have shown different extent of joint action in the mixtures.

Abstract (in Czech)

Studie prokázala vliv vybraných často užívaných léčiv, které mají potenciál dostávat se do prostředí, na produkci hormonů i na expresi klíčových enzymů steroidogeneze, což dokumentuje, že tato léčiva mohou mít vedlejší účinky na průběh steroidogeneze. Testy binárních směsí prokázaly různou míru spolupůsobení léčiv ve směsích.

Links

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)