| TSIKOURIS, Orestis, Tomáš BARTL, Jaromír TOUŠEK, Nikolaos LOUGIAKIS, Tony TITE, Panagiotis MARAKOS, Nicole POULI, Emmanuel MIKROS a Radek MAREK. NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Magnetic Resonance in Chemistry. John Wiley & Sons, 2008, roč. 46, č. 7, s. 643-649. ISSN 0749-1581. Dostupné z: https://dx.doi.org/10.1002/mrc.2226. |
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@article{763746,
author = {Tsikouris, Orestis and Bartl, Tomáš and Toušek, Jaromír and Lougiakis, Nikolaos and Tite, Tony and Marakos, Panagiotis and Pouli, Nicole and Mikros, Emmanuel and Marek, Radek},
article_number = {7},
doi = {http://dx.doi.org/10.1002/mrc.2226},
keywords = {NMR; 1H; 13C; 15N; tautomerism; spin-spin coupling constant; purine; pyrazolo[3.4-c]pyridine; quantum-chemical calculation},
language = {eng},
issn = {0749-1581},
journal = {Magnetic Resonance in Chemistry},
title = {NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives},
url = {http://dx.doi.org/10.1002/mrc.2226},
volume = {46},
year = {2008}
}
TY - JOUR
ID - 763746
AU - Tsikouris, Orestis - Bartl, Tomáš - Toušek, Jaromír - Lougiakis, Nikolaos - Tite, Tony - Marakos, Panagiotis - Pouli, Nicole - Mikros, Emmanuel - Marek, Radek
PY - 2008
TI - NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives
JF - Magnetic Resonance in Chemistry
VL - 46
IS - 7
SP - 643-649
EP - 643-649
PB - John Wiley & Sons
SN - 07491581
KW - NMR
KW - 1H
KW - 13C
KW - 15N
KW - tautomerism
KW - spin-spin coupling constant
KW - purine
KW - pyrazolo[3.4-c]pyridine
KW - quantum-chemical calculation
UR - http://dx.doi.org/10.1002/mrc.2226
L2 - http://dx.doi.org/10.1002/mrc.2226
N2 - Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the N1-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn.
ER -
TSIKOURIS, Orestis, Tomáš BARTL, Jaromír TOUŠEK, Nikolaos LOUGIAKIS, Tony TITE, Panagiotis MARAKOS, Nicole POULI, Emmanuel MIKROS a Radek MAREK. NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives. \textit{Magnetic Resonance in Chemistry}. John Wiley \&{} Sons, 2008, roč.~46, č.~7, s.~643-649. ISSN~0749-1581. Dostupné z: https://dx.doi.org/10.1002/mrc.2226.
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