Is there any link between severe pre-eclampsia and defined
polymorphisms in leptin and adiponectin genes?

J 2008

Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?

BIENERTOVÁ VAŠKŮ, Julie, Zuzana DOSTÁLOVÁ, Kateřina KAŇKOVÁ, Petr BIENERT, Anna VAŠKŮ et. al.

Basic information

Original name

Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?

Name in Czech

Polymorfismy v genech pro leptin a adiponectin a jejich vztah k závažné preeklampsii

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Zuzana DOSTÁLOVÁ (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic), Petr BIENERT (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic) and Vít UNZEITIG (203 Czech Republic)

Edition

The Journal of Obstetrics and Gynaecology Research, Japonsko, IngentaConnect, 2008, 1341-8076

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Japan

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.915

RIV identification code

RIV/00216224:14110/08:00033484

Organization unit

Faculty of Medicine

UT WoS

000259270800014

Keywords in English

adiponectin; leptin; polymorphism; preeclampsia

Abstract

ORIG CZ

V originále

Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important role in the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestational hypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus 0.583 in the control group (P = 0.578); the frequency of the APM1 94G polymorphism was 0.073 and 0.079 (P = 0.628), respectively. No significant associations were detected between either of the two single nucleotide polymorphisms or any of the parameter biomarkers related to pre-eclampsia, such as gestational hypertension or proteinuria. However, the APM1 T94G polymorphism was significantly associated with a low birth weight in pre-eclamptic pregnancies, with mothers carrying the T-allele having an almost three-fold increase in the likelihood of giving birth to a child with a low birth weight for its gestational age (odds ratio, 2.7; 95% confidence interval, 0.18 - 5.9; P = 0.004). Conclusions: The APM1 T94G and LEP -2548G/A polymorphisms do not seem to be major genetic determinants of susceptibility to pre-eclampsia in the Czech Caucasian population. However, evidence has been provided for possible APM1 T94G involvement in controlling the birth weight of children from pre-eclamptic pregnancies, thus supporting the hypothesis of T94G involvement in controlling the birth weight of newborns.

In Czech

Patofyziologie preeklampsie, jedné z nejčastějších příčin mateřské mortality po celém světě, je stále nejasná. V poslední době se objevily práce naznačující, že důležitou úlohu v rozvoji tohoto onemocnění hraje narušená regulace komplexních interakcí mezi různými adipokiny. Cílem této studie bylo prozkoumat, zda dva v populaci četné polymorfismy v genech pro leptin a adiponectin přispívají ke vzniku preeklampsie v české populaci.

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Zuzana DOSTÁLOVÁ, Kateřina KAŇKOVÁ, Petr BIENERT, Anna VAŠKŮ and Vít UNZEITIG. Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? The Journal of Obstetrics and Gynaecology Research. Japonsko: IngentaConnect, 2008, vol. 2008, XX, p. XXX, 8 pp. ISSN 1341-8076.

@article{767080,
   author = {Bienertová Vašků, Julie and Dostálová, Zuzana and Kaňková, Kateřina and Bienert, Petr and Vašků, Anna and Unzeitig, Vít},
   article_location = {Japonsko},
   article_number = {XX},
   keywords = {adiponectin; leptin; polymorphism; preeclampsia},
   language = {eng},
   issn = {1341-8076},
   journal = {The Journal of Obstetrics and Gynaecology Research},
   title = {Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?},
   volume = {2008},
   year = {2008}
}

TY  - JOUR
ID  - 767080
AU  - Bienertová Vašků, Julie - Dostálová, Zuzana - Kaňková, Kateřina - Bienert, Petr - Vašků, Anna - Unzeitig, Vít
PY  - 2008
TI  - Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
JF  - The Journal of Obstetrics and Gynaecology Research
VL  - 2008
IS  - XX
SP  - XXX
EP  - XXX
PB  - IngentaConnect
SN  - 13418076
KW  - adiponectin
KW  - leptin
KW  - polymorphism
KW  - preeclampsia
N2  - Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important role in the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestational hypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus 0.583 in the control group (P = 0.578); the frequency of the APM1 94G polymorphism was 0.073 and 0.079 (P = 0.628), respectively. No significant associations were detected between either of the two single nucleotide polymorphisms or any of the parameter biomarkers related to pre-eclampsia, such as gestational hypertension or proteinuria. However, the APM1 T94G polymorphism was significantly associated with a low birth weight in pre-eclamptic pregnancies, with mothers carrying the T-allele having an almost three-fold increase in the likelihood of giving birth to a child with a low birth weight for its gestational age (odds ratio, 2.7; 95% confidence interval, 0.18 - 5.9; P = 0.004). Conclusions: The APM1 T94G and LEP -2548G/A polymorphisms do not seem to be major genetic determinants of susceptibility to pre-eclampsia in the Czech Caucasian population. However, evidence has been provided for possible APM1 T94G involvement in controlling the birth weight of children from pre-eclamptic pregnancies, thus supporting the hypothesis of T94G involvement in controlling the birth weight of newborns.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Zuzana DOSTÁLOVÁ, Kateřina KAŇKOVÁ, Petr BIENERT, Anna VAŠKŮ and Vít UNZEITIG. Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes? \textit{The Journal of Obstetrics and Gynaecology Research}. Japonsko: IngentaConnect, 2008, vol.~2008, XX, p.~XXX, 8 pp. ISSN~1341-8076.

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