Two Common Polymorphisms Within The Adiponectin Gene Are
Associated With Food Preferences In Extremely Obese Czech
Individuals

D 2008

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT, Anna VAŠKŮ et. al.

Základní údaje

Originální název

Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals

Název česky

Dva v populaci četné polymorfismy v genu pro adiponektin jsou asociovány s potravními preferencemi u české extrémně obézní populace

Autoři

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT a Anna VAŠKŮ

Vydání

2008. vyd. Praha, 13th International SHR Symposium, od s. 85-85, 1 s. 2008

Nakladatel

Institute for Clinical and Experimental Physiology, Prague

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

Genetika a molekulární biologie

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

adiponectin; polymorphism; gene; obesity; food preferences

Štítky

adiponectin, food preferences, gene, obesity, polymorphism

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 6. 2008 22:49, prof. MUDr. Julie Dobrovolná, Ph.D.

Anotace

ORIG CZ

V originále

Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.

Česky

Získaná data naznačují silnou asociaci polymorfismů 45 T/G a 94 T/G v exonu 2 genu pro adiponektin s potravními preferencemi extrémně obézní české populace.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT a Anna VAŠKŮ. Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals. In 13th International SHR Symposium. 2008. vyd. Praha: Institute for Clinical and Experimental Physiology, Prague, 2008, s. 85-85.

@inproceedings{770181,
   author = {Bienertová Vašků, Julie and Bienert, Petr and Tomandl, Josef and Forejt, Martin and Vašků, Anna},
   address = {Praha},
   booktitle = {13th International SHR Symposium},
   edition = {2008},
   keywords = {adiponectin; polymorphism; gene; obesity; food preferences},
   language = {eng},
   location = {Praha},
   pages = {85-85},
   publisher = {Institute for Clinical and Experimental Physiology, Prague},
   title = {Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals},
   year = {2008}
}

TY  - JOUR
ID  - 770181
AU  - Bienertová Vašků, Julie - Bienert, Petr - Tomandl, Josef - Forejt, Martin - Vašků, Anna
PY  - 2008
TI  - Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals
PB  - Institute for Clinical and Experimental Physiology, Prague
CY  - Praha
KW  - adiponectin
KW  - polymorphism
KW  - gene
KW  - obesity
KW  - food preferences
N2  - Objectives: Considering the pivotal role of adiponectin in white adipose tissue metabolism and signaling, we assessed whether the 45T/G and 94T/G polymorphisms within the adiponectin gene influence the food preferences along with basic anthropometric characteristics in the Czech extremely obese population. Design and Methods: The total of 44 extremely obese subjects were enrolled in the study (BMI 46.03, SD 5.63; % of body fat 50.33, SD 5.13). Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7- day record method. The polymerase chain reaction-restriction fragment length polymorphism (PCR based RFLP) method was used to establish the distribution of allele and genotype frequencies of the 45T/G (exon 2) and 94T/G (exon 2) polymorphisms. ELISA was used to determine plasma levels of leptin and leptin receptor. Results: Both polymorphisms studied were significantly associated with various body size measurements including weight, waist and hip circumference, percentage of body fat and body mass index. Furthermore, the 45T/G was linked to the plasma levels of leptin receptor (beta = -0.36, p = 0.002). A strong effect of 94T/G on the food preferences of the morbidly obese individuals was observed, the 94T/G GG genotypes being significantly associated with the increased protein and carbohydrates intake (beta = -3.2, p = 0.02, beta = -5.5, p = 0.002, respectively). Conclusions: The obtained data well fit into a framework for food intake regulation and could provide possible targets for further nutrigenomical research and intervention focused on the food preferences.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Josef TOMANDL, Martin FOREJT a Anna VAŠKŮ. Two Common Polymorphisms Within The Adiponectin Gene Are Associated With Food Preferences In Extremely Obese Czech Individuals. In \textit{13th International SHR Symposium}. 2008. vyd. Praha: Institute for Clinical and Experimental Physiology, Prague, 2008, s.~85-85.

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