OŠLEJŠKOVÁ, Hana, Ladislav DUŠEK, Zuzana MAKOVSKÁ and Ivan REKTOR. Epilepsia, epileptiform abnormalities, non-right-handedness, hypotonia and severe decreased IQ are associated with language impairment in autism. Epileptic Disorders. France: Editions John Libbey Eurotext, 2007, vol. 2007, No 9, p. 9-18. ISSN 1294-9361.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Epilepsia, epileptiform abnormalities, non-right-handedness, hypotonia and severe decreased IQ are associated with language impairment in autism
Name in Czech Epilepsia, epileptiform abnormalities, non-right-handedness, hypotonia and severe decreased IQ are associated with language impairment in autism
Authors OŠLEJŠKOVÁ, Hana (203 Czech Republic, guarantor), Ladislav DUŠEK (203 Czech Republic), Zuzana MAKOVSKÁ (203 Czech Republic) and Ivan REKTOR (203 Czech Republic).
Edition Epileptic Disorders, France, Editions John Libbey Eurotext, 2007, 1294-9361.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.919
RIV identification code RIV/00216224:14110/07:00033607
Organization unit Faculty of Medicine
UT WoS 000254505000003
Keywords in English autism;speech impairment;epileptic seizures;hypotonia;handedness;IQ scoring
Tags Autism, epileptic seizures, handedness, hypotonia, IQ scoring, speech impairment
Changed by Changed by: prof. RNDr. Ladislav Dušek, Ph.D., učo 670. Changed: 1/4/2010 08:18.
Abstract
The aim of this study was to categorize speech problems in autistic children in a manner allowing recognition of associated risk factors. We were specifically interested in the role of epilepsy and epileptiform activity in EEG in autistic patients since these dynamic processes can influence each other. We combined subtypes of autism with degrees of their functionality and we selected three speech endpoints: i) delayed development of speech, ii) complete mutism and iii) regression of speech. We retrospectively examined 205 autistic children (boys 145/70.7%, mean age 10 years). Median IQ was 55 (15;104) and median Childhood Autism Rating Scale (CARS) ranged within 38 (32;48). Univariate and multivariate logistic regression helped to define clinical and diagnostic factors that were significantly associated with speech endpoints. Epileptic seizures, epileptiform EEG abnormalities, non-right-handedness, hypotonia and severe decreased IQ score were found to be the most important mutually independent factors contributing to the increased risk of speech-related problems in patients with ASD.
Abstract (in Czech)
The aim of this study was to categorize speech problems in autistic children in a manner allowing recognition of associated risk factors. We were specifically interested in the role of epilepsy and epileptiform activity in EEG in autistic patients since these dynamic processes can influence each other. We combined subtypes of autism with degrees of their functionality and we selected three speech endpoints: i) delayed development of speech, ii) complete mutism and iii) regression of speech. We retrospectively examined 205 autistic children (boys 145/70.7%, mean age 10 years). Median IQ was 55 (15;104) and median Childhood Autism Rating Scale (CARS) ranged within 38 (32;48). Univariate and multivariate logistic regression helped to define clinical and diagnostic factors that were significantly associated with speech endpoints. Epileptic seizures, epileptiform EEG abnormalities, non-right-handedness, hypotonia and severe decreased IQ score were found to be the most important mutually independent factors contributing to the increased risk of speech-related problems in patients with ASD.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
PrintDisplayed: 26/5/2024 15:35