VANČO, J., Jaromír MAREK, Z. TRÁVNÍČEK, E. RAČANSKÁ, J. MUSELÍK and O. ŠVAJLENOVÁ. Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine. Journal of Inorganic Biochemistry. Amsterdam: Elsevier Science, 2008, vol. 102, No 4, p. 595-605. ISSN 0162-0134.
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Basic information
Original name Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine
Name in Czech Syntézy, strukturní charakterizace a antiradikálové a antidiabetické aktivity měďnatých a zinečnatých komplexů Schiff. bazí odvozených od salicylaldehydu and beta-alaninu
Authors VANČO, J. (703 Slovakia), Jaromír MAREK (203 Czech Republic, guarantor), Z. TRÁVNÍČEK (203 Czech Republic), E. RAČANSKÁ (703 Slovakia), J. MUSELÍK (203 Czech Republic) and O. ŠVAJLENOVÁ (703 Slovakia).
Edition Journal of Inorganic Biochemistry, Amsterdam, Elsevier Science, 2008, 0162-0134.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10402 Inorganic and nuclear chemistry
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.133
RIV identification code RIV/00216224:14310/08:00026162
Organization unit Faculty of Science
UT WoS 000255131500001
Keywords in English copper(II); zinc(II); Schiff base; salicylaldehyde; beta-alanine; antioxidant activity; antidiabetic activity
Tags antidiabetic activity, antioxidant activity, beta-alanine, Copper(II), salicylaldehyde, Schiff base, zinc(II)
Changed by Changed by: doc. RNDr. Jaromír Marek, Ph.D., učo 1989. Changed: 25/6/2009 13:05.
Abstract
A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2), and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in the case of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.
Abstract (in Czech)
Byla připravena a fyzikálně-chemickými metodami charakterizována celá série měďnatých a zinečnatých komplexů obsahujících tridentátní O,N,O-donorovou Schiff. bázi odvozenou od salicylaldehydu and beta-alaninu. U všech sloučenin byla studována i jejich antiradikálová a antidiabetická aktivita.
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MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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