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@article{770899,
author = {Pásek, Michal and Šimurda, Jiří and Orchard, C. and Christé, G.},
article_location = {Great Britain},
article_number = {1-3},
keywords = {guinea pig; cardiac cell; transverse-axial tubular system; quantitative model},
language = {eng},
issn = {0079-6107},
journal = {Progress in Biophysics and Molecular Biology},
title = {A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system},
volume = {96},
year = {2008}
}
TY - JOUR
ID - 770899
AU - Pásek, Michal - Šimurda, Jiří - Orchard, C. - Christé, G.
PY - 2008
TI - A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system
JF - Progress in Biophysics and Molecular Biology
VL - 96
IS - 1-3
SP - 258-280
EP - 258-280
PB - Elsevier Ltd.
SN - 00796107
KW - guinea pig
KW - cardiac cell
KW - transverse-axial tubular system
KW - quantitative model
N2 - A model of guinea-pig cardiac ventricular myocyte incorporating a transverse-axial tubular system (TATS) was developed. The model reproduces frequency-dependent changes of action potential shape and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes.Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp. However, during action potentials, restricted diffusion and ionic currents in TATS cause depletion of tubular Ca2+ and accumulation of tubular K+ (up to 19.8% and +3.4%, respectively, of bulk extracellular values, at 6 Hz). These changes, in turn, decrease ion fluxes across the TATS membrane and decrease sarcoplasmic reticulum (SR) Ca2+ load. Thus, the TATS plays a potentially important role in modulating the function of guinea-pig ventricular myocyte in physiological conditions.
ER -
PÁSEK, Michal, Jiří ŠIMURDA, C. ORCHARD and G. CHRISTÉ. A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse-axial tubular system. \textit{Progress in Biophysics and Molecular Biology}. Great Britain: Elsevier Ltd., 2008, vol.~96, 1-3, p.~258-280. ISSN~0079-6107.
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