J 2007

Longterm treatment results of childhood medulloblastoma by craniospinal irradiation in supine position.

ŠLAMPA, Pavel, Zdeněk PAVELKA, Ladislav DUŠEK, Ludmila HYNKOVÁ, Jaroslav ŠTĚRBA et. al.

Basic information

Original name

Longterm treatment results of childhood medulloblastoma by craniospinal irradiation in supine position.

Name in Czech

Dlouhodobé výsledky léčby dětí s meduloblastomem radioterapií kraniospinální osy v supinační posici.

Name (in English)

Longterm treatment results of childhood medulloblastoma by craniospinal irradiation in supine position.

Authors

ŠLAMPA, Pavel, Zdeněk PAVELKA, Ladislav DUŠEK, Ludmila HYNKOVÁ, Jaroslav ŠTĚRBA, Barbora ONDROVÁ, Denis PRINC, Zuzana KOŠŤÁKOVÁ and Tomáš NOVOTNÝ

Edition

Neoplasma, 2007, 0028-2685

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.208

Organization unit

Faculty of Medicine

UT WoS

000246073100010

Keywords in English

medulloblastoma radiotherapy craniospinal irradiation
Změněno: 9/2/2017 14:56, Mgr. Michal Petr

Abstract

ORIG EN

V originále

Medulloblastoma, a primitive neuroectodermal tumor growing in cerebellum, is one of the most sensitive to radiation therapy childhood brain tumors. The radiotherapy is an essential method of treatment for these tumours, but the surgery is the primary treatment of choice in medulloblastoma. I this study between January 1997 and March 2005 were post-operative irradiated a total number of 33 pediatric patients aged under 15 years (median age 8.7 years) with medulloblastoma. All tumors were histologically proved and were localizated infratentorially in the posterior fossa. All of the patients were irradiated with a dose of 24-36 Gy to the whole craniospinal axis and boost with conformal therapy restricted to the tumor bed to the total dose of 50-54 Gy (30-36 Gy “high risk”, 24-30 Gy “standard risk” group). Chemotherapy received 26 patients (78%). Patients with craniospinal irradiation were placed in supine position and fixed by a vacuum-form body immobilizer and head mask. Irradiation was performed using standard fractionation (5 fractions per week) with a single dose of 1.5-1.8 Gy for craniospinal axis by photon beam (6 MV) of the linear accelerator. The median overall survival for the whole group was 55.3 months. The median of disease-free survival was 20.6 months, 8 patients (24%) died. In our study the statistical difference in survival rate between standard and high-risk patients with medulloblastoma was not shown. No relationship was found between survival and age, sex or tumor size. Endocrine deficits occurred in 45% (8 patients of the group were hypothyroid, 6 patients needed growth hormone replacement therapy, 1 patient had early puberty). This results (results of overall and disease-free survival) and side-effects of technique of craniospinal axis irradiation in supine position are comparable with results of technique in prone position. Further evaluation of the effectiveness of our therapy is not feasible due to the small number of patients.

In English

Analysis of our own longterm treatment results of children with medulloblastoma treated by cranospinal irradiation in supine position.

Links

NR9125, research and development project
Name: Diagnostický a prediktivní význam molekulárně cytogenetických markerů u embryonálních nádorů dětského věku.
Investor: Ministry of Health of the CR