ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ, Ondřej LUDKA, Josef TOMANDL a Jiří VÍTOVEC. Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Experimental and Molecular Pathology. USA: The Human Press, 2008, roč. 84, č. 7, s. 250-255. ISSN 0014-4800. |
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@article{771712, author = {Špinarová, Lenka and Špinar, Jindřich and Vašků, Anna and Pávková Goldbergová, Monika and Ludka, Ondřej and Tomandl, Josef and Vítovec, Jiří}, article_location = {USA}, article_number = {7}, keywords = {Genetics;cytokines;chronic hear failure;stratification}, language = {eng}, issn = {0014-4800}, journal = {Experimental and Molecular Pathology}, title = {Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients}, volume = {84}, year = {2008} }
TY - JOUR ID - 771712 AU - Špinarová, Lenka - Špinar, Jindřich - Vašků, Anna - Pávková Goldbergová, Monika - Ludka, Ondřej - Tomandl, Josef - Vítovec, Jiří PY - 2008 TI - Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients JF - Experimental and Molecular Pathology VL - 84 IS - 7 SP - 250-255 EP - 250-255 PB - The Human Press SN - 00144800 KW - Genetics;cytokines;chronic hear failure;stratification N2 - Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p < 0.05). Patients with IHD and DM had allele G in 0.67 and A 0.33, while those without DM had allele G in 0.790 and A in 0.209 (p < 0.03). Patients with IHD and concomitant PAD had allele G in 0.718 and A in 0.282 vs those without PAD allele G in 0.882 and A in 0.118 (p < 0.0004). Patients with dilative cardiomyopathy (DCMP) showed no differences in genotype G8002A and presence of DM or PAD. It might be speculated that in the case of endothelin-1 and TNF alpha in CHF the genetic determination is not important, and plasma concentrations are influenced more by the disease severity. Ischemics with previous MI, concomitant DM or PAD showed more frequently allele A and less often allele G than those without these diseases. A genotype with allele A is associated with higher risk of concomitant diseases. ER -
ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Anna VAŠKŮ, Monika PÁVKOVÁ GOLDBERGOVÁ, Ondřej LUDKA, Josef TOMANDL a Jiří VÍTOVEC. Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. \textit{Experimental and Molecular Pathology}. USA: The Human Press, 2008, roč.~84, č.~7, s.~250-255. ISSN~0014-4800.
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