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@article{772083,
author = {Ondřej, Vladan and Lukášová, Emilie and Krejčí, Jana and Matula, Pavel and Kozubek, Stanislav},
article_number = {4},
keywords = {lamin A/C; polymeric actin; chromosome territories; nuclear organization},
language = {eng},
issn = {1016-8478},
journal = {Molecules and Cells},
title = {Lamin A/C and polymeric actin in genome organization},
volume = {26},
year = {2008}
}
TY - JOUR
ID - 772083
AU - Ondřej, Vladan - Lukášová, Emilie - Krejčí, Jana - Matula, Pavel - Kozubek, Stanislav
PY - 2008
TI - Lamin A/C and polymeric actin in genome organization
JF - Molecules and Cells
VL - 26
IS - 4
SP - 356-361
EP - 356-361
SN - 10168478
KW - lamin A/C
KW - polymeric actin
KW - chromosome territories
KW - nuclear organization
N2 - In this work, we have studied the structural and functional linkage between lamin A/C, nuclear actin, and organization of chromosome territories (CTs) in mammary carcinoma MCF-7 cells. Selective down-regulation of lamin A/C expression led to disruption of the lamin A/C perinuclear layer and disorganization of lamin-bound emerin complexes at the inner nuclear membrane. The silencing of lamin A/C expression resulted in a decrease in the volume and surface area of chromosome territories, especially in chromosomes with high heterochromatin content. Inhibition of actin polymerization led to relaxation of the structure of chromosome territories, and an increase in the volumes and surface areas of the chromosome territories of human chromosomes 1, 2 and 13. The results show an important role of polymeric actin in the organization of the nuclei and the chromosome territories.
ER -
ONDŘEJ, Vladan, Emilie LUKÁŠOVÁ, Jana KREJČÍ, Pavel MATULA and Stanislav KOZUBEK. Lamin A/C and polymeric actin in genome organization. \textit{Molecules and Cells}. 2008, vol.~26, No~4, p.~356-361. ISSN~1016-8478.
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