Toll-like receptor stimulation induces higher TNF-alpha
secretion in peripheral blood mononuclear cells from patients
with hyper IgE syndrome.

J 2008

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL et. al.

Základní údaje

Originální název

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

Název česky

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Autoři

YEGANEH, Mehdi (364 Írán), Philip HENNEKE (276 Německo), Nima REZAEI (364 Írán), Stephan EHL (276 Německo), Doerte THIEL (276 Německo), Nuria MATAMOROS (724 Španělsko), Cristina PIETROGRADA (380 Itálie), Teresa ESPANOL (724 Španělsko), Jiří LITZMAN (203 Česká republika, garant), Jose L. FRANCO (170 Kolumbie), Ozden SANAL (792 Turecko), Sara S. KILIC (792 Turecko), Anna BREBOROWICZ (792 Turecko), Alessandro BLEBANI (380 Itálie), Ellen RENNER (276 Německo), Simon ROTHENFUSSER (276 Německo), Thomas R. RAWN (840 Spojené státy), Cristina WOELLNER (826 Velká Británie a Severní Irsko) a Bodo GRIMBACHER (826 Velká Británie a Severní Irsko)

Vydání

International Archives Allergy and Immunology, Basel, Karger AG, 2008, 1018-2438

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.131

Kód RIV

RIV/00216224:14110/08:00028225

Organizační jednotka

Lékařská fakulta

UT WoS

000255896000002

Klíčová slova anglicky

Hyper IgE syndrome; Toll-like receptor;TNF alpha

Štítky

hyper IgE syndrome, TNF alpha, toll-like receptor

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 4. 2010 08:03, prof. MUDr. Jiří Litzman, CSc.

Anotace

ORIG CZ

V originále

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.

Česky

Stimulace Toll-like receptorů periferních mononukleárů pacientů s hyper IgE syndromem vede k tvorbě TNF alfa

Návaznosti

NR9192, projekt VaV

Název: Screening mutací a polymorfismů v genu pro neonatální Fc receptor u pacientů s primárními poruchami tvorby protilátek

Citovat

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER a Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. International Archives Allergy and Immunology. Basel: Karger AG, 2008, roč. 146, č. 3, s. 190-194. ISSN 1018-2438.

@article{772327,
   author = {Yeganeh, Mehdi and Henneke, Philip and Rezaei, Nima and Ehl, Stephan and Thiel, Doerte and Matamoros, Nuria and Pietrograda, Cristina and Espanol, Teresa and Litzman, Jiří and Franco, Jose L. and Sanal, Ozden and Kilic, Sara S. and Breborowicz, Anna and Blebani, Alessandro and Renner, Ellen and Rothenfusser, Simon and Rawn, Thomas R. and Woellner, Cristina and Grimbacher, Bodo},
   article_location = {Basel},
   article_number = {3},
   keywords = {Hyper IgE syndrome; Toll-like receptor;TNF alpha},
   language = {eng},
   issn = {1018-2438},
   journal = {International Archives Allergy and Immunology},
   title = {Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.},
   volume = {146},
   year = {2008}
}

TY  - JOUR
ID  - 772327
AU  - Yeganeh, Mehdi - Henneke, Philip - Rezaei, Nima - Ehl, Stephan - Thiel, Doerte - Matamoros, Nuria - Pietrograda, Cristina - Espanol, Teresa - Litzman, Jiří - Franco, Jose L. - Sanal, Ozden - Kilic, Sara S. - Breborowicz, Anna - Blebani, Alessandro - Renner, Ellen - Rothenfusser, Simon - Rawn, Thomas R. - Woellner, Cristina - Grimbacher, Bodo
PY  - 2008
TI  - Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.
JF  - International Archives Allergy and Immunology
VL  - 146
IS  - 3
SP  - 190-194
EP  - 190-194
PB  - Karger AG
SN  - 10182438
KW  - Hyper IgE syndrome
KW  - Toll-like receptor;TNF alpha
N2  - Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
ER  -

YEGANEH, Mehdi, Philip HENNEKE, Nima REZAEI, Stephan EHL, Doerte THIEL, Nuria MATAMOROS, Cristina PIETROGRADA, Teresa ESPANOL, Jiří LITZMAN, Jose L. FRANCO, Ozden SANAL, Sara S. KILIC, Anna BREBOROWICZ, Alessandro BLEBANI, Ellen RENNER, Simon ROTHENFUSSER, Thomas R. RAWN, Cristina WOELLNER a Bodo GRIMBACHER. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. \textit{International Archives Allergy and Immunology}. Basel: Karger AG, 2008, roč.~146, č.~3, s.~190-194. ISSN~1018-2438.

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