Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population

BIENERTOVÁ VAŠKŮ, Julie, Lenka ŠPINAROVÁ, Petr BIENERT and Anna VAŠKŮ. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. Heart Vessels. Japonsko: Springer Japan, 2009, 24/2009, No 2, p. 131-137. ISSN 0910-8327.

Basic information

Original name

Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population

Name in Czech

Asociace mezi polymorfismy v genech kódujících leptin, leptinový receptor a proopiomelanokortin a chronickým srdečním selháním u České populace

Authors

BIENERTOVÁ VAŠKŮ, Julie (203 Czech Republic, guarantor), Lenka ŠPINAROVÁ (203 Czech Republic), Petr BIENERT (203 Czech Republic) and Anna VAŠKŮ (203 Czech Republic)

Edition

Heart Vessels, Japonsko, Springer Japan, 2009, 0910-8327

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Japan

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.716

RIV identification code

RIV/00216224:14110/09:00033786

Organization unit

Faculty of Medicine

UT WoS

000264836000010

Keywords in English

Adipokines ; Polymorphisms; Leptin; Leptin receptor; Proopiomelanocortin; Chronic heart failure

Tags

adipokines, chronic heart failure, leptin, leptin receptor, polymorphisms, proopiomelanocortin

Tags

International impact, Reviewed

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Abstract

V originále

Patients with chronic heart failure (CHF) express enhanced catabolic metabolism finally resulting in overall weight loss, whereas adipokines might play a crucial role in signaling among tissues. The role of the polymorphic variants in the genes encoding for adipokines as potential CHF susceptibility genes is unclear. Based on our findings, the LEPR Gln223Arg polymorphism could be considered a disease susceptibility modulating factor both in ischemic heart disease or dilated cardiomyopathy patients.

In Czech

Studie sleduje souvislost mezi geny podílejícími se na kontrole energetické homeostázy organismu a chronickým srdečním selháním v české populaci.