ANANTHALAKSHMI, Kethireddy V. V., Tomáš BARTL, Mohammed H. AZIZA, Ladislav NOVOTNÝ, Radek MAREK, Luděk BENEŠ a Samuel B. KOMBIAN. Synthesis and structure_activity relationship studies of theophylline analogs. Bioorganic & Medicinal Chemistry. Elsevier, 2008, roč. 16, č. 17, s. 8142-8150. ISSN 0968-0896. |
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@article{776763, author = {Ananthalakshmi, Kethireddy V. V. and Bartl, Tomáš and Aziza, Mohammed H. and Novotný, Ladislav and Marek, Radek and Beneš, Luděk and Kombian, Samuel B.}, article_number = {17}, keywords = {Hippocampus; Acetylcholine receptors; Dementia; Nootropic; Theophylline analogs}, language = {eng}, issn = {0968-0896}, journal = {Bioorganic & Medicinal Chemistry}, title = {Synthesis and structure_activity relationship studies of theophylline analogs}, volume = {16}, year = {2008} }
TY - JOUR ID - 776763 AU - Ananthalakshmi, Kethireddy V. V. - Bartl, Tomáš - Aziza, Mohammed H. - Novotný, Ladislav - Marek, Radek - Beneš, Luděk - Kombian, Samuel B. PY - 2008 TI - Synthesis and structure_activity relationship studies of theophylline analogs JF - Bioorganic & Medicinal Chemistry VL - 16 IS - 17 SP - 8142-8150 EP - 8142-8150 PB - Elsevier SN - 09680896 KW - Hippocampus KW - Acetylcholine receptors KW - Dementia KW - Nootropic KW - Theophylline analogs N2 - We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers. ER -
ANANTHALAKSHMI, Kethireddy V. V., Tomáš BARTL, Mohammed H. AZIZA, Ladislav NOVOTNÝ, Radek MAREK, Luděk BENEŠ a Samuel B. KOMBIAN. Synthesis and structure\_{}activity relationship studies of theophylline analogs. \textit{Bioorganic \&{} Medicinal Chemistry}. Elsevier, 2008, roč.~16, č.~17, s.~8142-8150. ISSN~0968-0896.
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