k 2008

Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.

BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ, Radim JANČÁLEK et. al.

Basic information

Original name

Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.

Name in Czech

Změny IL-6 a jeho receptoru ve spinálních gangliích potkana po ligatuře spinálního nervu.

Authors

BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ, Radim JANČÁLEK and Petr DUBOVÝ

Edition

6th International Symposium on Experimental and Clinical Neurobiology, 2008

Other information

Language

English

Type of outcome

Prezentace na konferencích

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

ISBN

978-80-7399-489-1

Keywords in English

neuropathic pain, sciatic nerve ligature, IL-6 protein, gp130
Změněno: 22/9/2008 17:12, Mgr. Zuzana Štumpfová

Abstract

V originále

Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model.

Links

GA309/07/0121, research and development project
Name: Změny cytokinů ve spinálních gangliích experimentálních modelů neuropatické bolesti indukované unilaterálním poškozením nervu
Investor: Czech Science Foundation, Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury
MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.