Effect of rimonabant on social behaviour in the olfactory bulbectomy model of depression in mice

PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. Effect of rimonabant on social behaviour in the olfactory bulbectomy model of depression in mice. The International Journal of Neuropsychopharmacology. Cambridge: Cambridge University Press, 2008, vol. 11, Suppl.1, p. 126. ISSN 1461-1457.

Basic information

• Original name: Effect of rimonabant on social behaviour in the olfactory bulbectomy model of depression in mice
• Name in Czech: Účinky rimonabantu na sociální chování v myším modelu deprese - olfaktorické bulbektomie
• Authors: PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ.
• Edition: The International Journal of Neuropsychopharmacology, Cambridge, Cambridge University Press, 2008, 1461-1457.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.378
• Organization unit: Faculty of Medicine
• UT WoS: 000258855500521
• Keywords in English: rimonabant; animal model; mice; depression; social behaviour
• Tags: animal model, Depression, mice, rimonabant, social behaviour
• Tags: International impact

Abstract

The study was undertaken to evaluate the applicability of a combination of the olfactory bulbectomy animal model of depression and agonistic interactions behavioural paradigm in mice for screening drugs for their potential anxiolytic and antidepressant effects. We tested CB1 cannabinoid receptor antagonist rimonabant (SR141716), which may also have antidepressant activity. The behavioural changes induced by olfactory bulbectomy in mice were inhibited by chronic treatment with rimonabant, which suggests an antidepressant-like drug effect in this model of depression. Rimonabant treatment was not able to compensate the anxiogenic effects induced by olfactory bulbectomy, neither it influenced behavioural activities in the sham-operated mice. The data support that the use of the OB mice in combination with the agonistic interactions model can be beneficial for identifying antidepressants compounds with anxiolytic/antidepressant actions.

Abstract (in Czech)

Naše studie sledovala využitelnost kombinace zvířecího modelu deprese - bilaterální olfaktorické bulbektomie s modelem agonistických interakcí u myší ke skríninku látek s potenciální anxiolytickou a antidepresivní aktivitou. K testování jsme použili antagonistu kanabinoidních CB1 receptorů rimonabant (SR141716). Anxiogenní projevy navozené olfaktorickou bulbektomií u myší nebyly inhibovány chronickým podáváním rimonabantu. Rimonabant projevil účinky, která pozorujeme u klasických antidepresiv. Kombinace obou modelů se ukázala jako užitečná pro odhad možných antidepresivních, resp. anxiolytických účinků testovaných látek.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.