| PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats. European Neuropsychopharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2008, roč. 18, Suppl.4, s. S258, 1 s. ISSN 0924-977X. |
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@article{779512,
author = {Pistovčáková, Jana and Šulcová, Alexandra},
article_location = {Amsterdam, The Netherlands},
article_number = {Suppl.4},
keywords = {aripiprazole; olfactory bulbectomy; immunity; behaviour; depression; animal model},
language = {eng},
issn = {0924-977X},
journal = {European Neuropsychopharmacology},
title = {Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats},
volume = {18},
year = {2008}
}
TY - JOUR
ID - 779512
AU - Pistovčáková, Jana - Šulcová, Alexandra
PY - 2008
TI - Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats
JF - European Neuropsychopharmacology
VL - 18
IS - Suppl.4
SP - S258
EP - S258
PB - Elsevier Science B.V.
SN - 0924977X
KW - aripiprazole
KW - olfactory bulbectomy
KW - immunity
KW - behaviour
KW - depression
KW - animal model
N2 - Aripiprazole is an atypical antipsychotic, which displays partial agonist activity at the dopamine D2 receptor and is approved also for the treatment of affective disorders. Present study was undertaken to evaluate the applicability of the well-established olfactory bulbectomy (OB) rat model of experimental depression for the assessment of aripiprazole antidepressant effects. Since the affective disorders are often accompanied by the immune system dysfunction [2], the leukocyte phagocytosis representing the cell immune function was measured together with the behavioural changes. Aripiprazole exhibited a significant positive influence on the impaired behavioural and immune changes in the OB rats serving as model of depression. Thus, chronic treatment with this antipsychotic drug can modulate the cell immune function, which may add to its clinical efficacy.
ER -
PISTOVČÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Effect of aripiprazole on behaviour and leukocyte phagocytosis in the olfactory bulbectomy model of depression in rats. \textit{European Neuropsychopharmacology}. Amsterdam, The Netherlands: Elsevier Science B.V., 2008, roč.~18, Suppl.4, s.~S258, 1 s. ISSN~0924-977X.
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