DNA interactions of new antitumor platinum complexes with trans
geometry activated by a 2-metylbutylamine or sec-butylamine
ligand.

J 2004

DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.

PROKOP, Radim, Jana KAŠPÁRKOVÁ, Olga NOVAKOVA, María Victoria MARINI PALOMEQUE, Ana M. PIZARRO et. al.

Základní údaje

Originální název

DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.

Název česky

Interakce novych protinadorovych platinovych komplexu s DNA

Autoři

PROKOP, Radim (203 Česká republika), Jana KAŠPÁRKOVÁ (203 Česká republika), Olga NOVAKOVA (203 Česká republika), María Victoria MARINI PALOMEQUE (858 Uruguay), Ana M. PIZARRO (724 Španělsko), Carmen NAVARRO-RANNINGER (724 Španělsko) a Viktor BRABEC (203 Česká republika, garant)

Vydání

Biochemical Pharmacology, Oxford, UK, Elsevier, 2004, 0006-2952

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.436

Kód RIV

RIV/00216224:14310/04:00029123

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000220333900012

Klíčová slova anglicky

cisplatin; platinum complexes; DNA; antitumor

Štítky

antitumor, cisplatin, DNA, platinum complexes

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 1. 2009 14:32, Mgr. María Victoria Marini Palomeque, Ph.D.

Anotace

ORIG CZ

V originále

The global modification of mammalian and plasmid DNAs by novel platinum compounds, trans-[PtCl(2)(NH(3))(Am)], where Am=2 -methylbutylamine or sec-butylamine was investigated in cell-free media using various biochemical and biophysical methods. These modifications were analyzed in the context of the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin). The results showed that the replacement of one amine group by 2-methylbutylamine or sec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA. The results support the view that one strategy to activate trans geometry in bifunctional platinum(II) compounds including circumvention of resistance to cisplatin may consist in a chemical modification of the ineffective transplatin which results in an increased efficiency to form DNA interstrand cross-links.

Česky

Návaznosti

GA305/02/1552, projekt VaV

Název: Oligonukleotidy modifikované komplexy platiny pro selektivní modulaci genové exprese; vztah k "protismyslné" strategii při vývoji nových farmak.

Citovat

PROKOP, Radim, Jana KAŠPÁRKOVÁ, Olga NOVAKOVA, María Victoria MARINI PALOMEQUE, Ana M. PIZARRO, Carmen NAVARRO-RANNINGER a Viktor BRABEC. DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. Biochemical Pharmacology. Oxford, UK: Elsevier, 2004, roč. 67, č. 6, s. 1097-109, 13 s. ISSN 0006-2952.

@article{792965,
   author = {Prokop, Radim and Kašpárková, Jana and Novakova, Olga and Marini Palomeque, María Victoria and Pizarro, Ana M. and NavarroandRanninger, Carmen and Brabec, Viktor},
   article_location = {Oxford, UK},
   article_number = {6},
   keywords = {cisplatin; platinum complexes; DNA; antitumor},
   language = {eng},
   issn = {0006-2952},
   journal = {Biochemical Pharmacology},
   title = {DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.},
   volume = {67},
   year = {2004}
}

TY  - JOUR
ID  - 792965
AU  - Prokop, Radim - Kašpárková, Jana - Novakova, Olga - Marini Palomeque, María Victoria - Pizarro, Ana M. - Navarro-Ranninger, Carmen - Brabec, Viktor
PY  - 2004
TI  - DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
JF  - Biochemical Pharmacology
VL  - 67
IS  - 6
SP  - 1097-109
EP  - 1097-109
PB  - Elsevier
SN  - 00062952
KW  - cisplatin
KW  - platinum complexes
KW  - DNA
KW  - antitumor
N2  - The global modification of mammalian and plasmid DNAs by novel platinum compounds, trans-[PtCl(2)(NH(3))(Am)], where Am=2 -methylbutylamine or sec-butylamine was investigated in cell-free media using various biochemical and biophysical methods. These modifications were analyzed in the context of the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin). The results showed that the replacement of one amine group by 2-methylbutylamine or sec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA. The results support the view that one strategy to activate trans geometry in bifunctional platinum(II) compounds including circumvention of resistance to cisplatin may consist in a chemical modification of the ineffective transplatin which results in an increased efficiency to form DNA interstrand cross-links.
ER  -

PROKOP, Radim, Jana KAŠPÁRKOVÁ, Olga NOVAKOVA, María Victoria MARINI PALOMEQUE, Ana M. PIZARRO, Carmen NAVARRO-RANNINGER a Viktor BRABEC. DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. \textit{Biochemical Pharmacology}. Oxford, UK: Elsevier, 2004, roč.~67, č.~6, s.~1097-109, 13 s. ISSN~0006-2952.

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