VAŠKŮ, Vladimír, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma. International Journal of Clinical and Experimental Pathology. USA: e-Century Publishing Corporation, Madiso, 2009, roč. 2/2009, č. 2, s. 163-168. ISSN 1936-2625. |
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@article{796183, author = {Vašků, Vladimír and Vašků, Anna and Bienertová Vašků, Julie}, article_location = {USA}, article_number = {2}, keywords = {leptin; gene polymorphism; pharmacogenetics; cutaneous T-cell lymphoma}, language = {eng}, issn = {1936-2625}, journal = {International Journal of Clinical and Experimental Pathology}, title = {Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma}, volume = {2/2009}, year = {2009} }
TY - JOUR ID - 796183 AU - Vašků, Vladimír - Vašků, Anna - Bienertová Vašků, Julie PY - 2009 TI - Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma JF - International Journal of Clinical and Experimental Pathology VL - 2/2009 IS - 2 SP - 163-168 EP - 163-168 PB - e-Century Publishing Corporation, Madiso SN - 19362625 KW - leptin KW - gene polymorphism KW - pharmacogenetics KW - cutaneous T-cell lymphoma N2 - Abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95% confidential interval 1.51-41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A polymorphism in CTCL treatment responsiveness and thus might provide important information for individual therapy tailoring. ER -
VAŠKŮ, Vladimír, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell Lymphoma. \textit{International Journal of Clinical and Experimental Pathology}. USA: e-Century Publishing Corporation, Madiso, 2009, roč.~2/2009, č.~2, s.~163-168. ISSN~1936-2625.
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