C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions

KADEŘÁVEK, Pavel and Radovan FIALA. C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions. In XXIII International Conference on Magnetic Resonance in Biological Systems. San Diego: ICMRBS, 2008, p. 117.

Basic information

• Original name: C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions
• Name in Czech: Studium dynamiky RNA pomocí relaxace C-13: Problémy a jejich řešení
• Authors: KADEŘÁVEK, Pavel and Radovan FIALA.
• Edition: San Diego, XXIII International Conference on Magnetic Resonance in Biological Systems, p. 117-117, 2008.
• Publisher: ICMRBS

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 10610 Biophysics
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Organization unit: Faculty of Science
• Keywords in English: NMR; nucleic acids;RNA;dynamics
• Tags: dynamics, NMR, nucleic acids, RNA
• Tags: International impact

Abstract

NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter.

Abstract (in Czech)

NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter.

Links

• LC06030, research and development project: Name: Biomolekulární centrum

Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre

• MSM0021622413, plan (intention): Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment