2009
Survival and infertility treatment in male cancer patients after sperm banking
CRHA, Igor, Pavel VENTRUBA, Martin HUSER, Jana ŽÁKOVÁ, Robert HUDEČEK et. al.Základní údaje
Originální název
Survival and infertility treatment in male cancer patients after sperm banking
Název česky
Survival and infertility treatment in male cancer patients after sperm banking
Autoři
CRHA, Igor (203 Česká republika, garant, domácí), Pavel VENTRUBA (203 Česká republika, domácí), Martin HUSER (203 Česká republika, domácí), Jana ŽÁKOVÁ (203 Česká republika, domácí), Robert HUDEČEK (203 Česká republika, domácí) a Jiří JARKOVSKÝ (203 Česká republika, domácí)
Vydání
Fertility and Sterility, 2009, 1556-5653
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30214 Obstetrics and gynaecology
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 3.970
Kód RIV
RIV/00216224:14110/09:00034393
Organizační jednotka
Lékařská fakulta
UT WoS
000266801400009
Klíčová slova česky
cryopreservation; semen; cancer survivors; male infertility
Klíčová slova anglicky
cryopreservation; semen; cancer survivors; male infertility
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 6. 2. 2019 10:46, Mgr. Michal Petr
V originále
OBJECTIVE: The main aim of the study was to evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank. DESIGN: Prospective study. SETTING: University fertility center. PATIENT(S): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006. INTERVENTION(S): Semen analysis, data verification in the National Oncological Register, assisted reproduction techniques, statistical evaluation. MAIN OUTCOME MEASURE(S): Cancer diagnosis and sperm pathology analysis, survival of patients and infertility treatment. RESULT(S): Malignant testicular cancer was diagnosed in 43.6% of patients, while malignant neoplasms of the lymphatic and haematopoietic tissues were found in 31.7% of patients. Azoospermia, or severe oligospermia were detected in 9.7% and 22.6% of patients, respectively. Until now, 32 patients (5.2%) have attended for infertility treatment. Cryopreserved semen was used in 28 couples (87.5%), 44 ICSI cycles resulted in 13 pregnancies. In total, 74 deaths (11.9%) were reported, 61 of them (82.4%) within 30 months of the cryopreservation of their sperm. CONCLUSION(S): Significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries.
Česky
OBJECTIVE: The main aim of the study was to evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank. DESIGN: Prospective study. SETTING: University fertility center. PATIENT(S): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006. INTERVENTION(S): Semen analysis, data verification in the National Oncological Register, assisted reproduction techniques, statistical evaluation. MAIN OUTCOME MEASURE(S): Cancer diagnosis and sperm pathology analysis, survival of patients and infertility treatment. RESULT(S): Malignant testicular cancer was diagnosed in 43.6% of patients, while malignant neoplasms of the lymphatic and haematopoietic tissues were found in 31.7% of patients. Azoospermia, or severe oligospermia were detected in 9.7% and 22.6% of patients, respectively. Until now, 32 patients (5.2%) have attended for infertility treatment. Cryopreserved semen was used in 28 couples (87.5%), 44 ICSI cycles resulted in 13 pregnancies. In total, 74 deaths (11.9%) were reported, 61 of them (82.4%) within 30 months of the cryopreservation of their sperm. CONCLUSION(S): Significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries.
Návaznosti
| MSM0021622412, záměr |
|