Modelling the cardiac transverse-axial tubular system

J 2008

Modelling the cardiac transverse-axial tubular system

PÁSEK, Michal; Jiří ŠIMURDA; Georges CHRISTÉ a Clive ORCHARD

Základní údaje

Originální název

Modelling the cardiac transverse-axial tubular system

Název česky

Modelování transverzálně-axiálního tubulárního systému u srdečních buněk

Autoři

PÁSEK, Michal (203 Česká republika, garant); Jiří ŠIMURDA (203 Česká republika, domácí); Georges CHRISTÉ (250 Francie) a Clive ORCHARD (826 Velká Británie a Severní Irsko)

Vydání

Progress in Biophysics and Molecular Biology, Great Britain, Elsevier Ltd. 2008, 0079-6107

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 6.388

Kód RIV

RIV/00216224:14110/08:00024385

Organizační jednotka

Lékařská fakulta

UT WoS

000254598000013

Klíčová slova anglicky

cardiac cell; transverse-axial tubular system; quantitative modelling

Štítky

Cardiac cell, Quantitative modelling, transverse-axial tubular system

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 30. 12. 2012 17:34, doc. Ing. Michal Pásek, Ph.D.

Anotace

ORIG CZ

V originále

The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental evidence is lacking, computer models provide a method to assess and predict the possible function of the TATS; such models suggest that although the surface and TATS membranes are electrically well coupled, concentration of ion flux pathways within the TATS, coupled to restricted diffusion, may result in the ionic composition in the TATS lumen being different from that in the bulk extracellular space, and varying with activity and in pathological conditions.

Česky

Práce shrnuje nejnovější výsledky výpočtového modelování funkce transverzálně-axiálního tubulárního systému u srdečních komorových buněk a vytyčuje nové otázky ve výzkumu jeho fyziologické role.

Návaznosti

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

PÁSEK, Michal; Jiří ŠIMURDA; Georges CHRISTÉ a Clive ORCHARD. Modelling the cardiac transverse-axial tubular system. Progress in Biophysics and Molecular Biology. Great Britain: Elsevier Ltd., 2008, roč. 96, 1-3, s. 226-243, 17 s. ISSN 0079-6107.

@article{807504,
   author = {Pásek, Michal and Šimurda, Jiří and Christé, Georges and Orchard, Clive},
   article_location = {Great Britain},
   article_number = {1-3},
   keywords = {cardiac cell; transverse-axial tubular system; quantitative modelling},
   language = {eng},
   issn = {0079-6107},
   journal = {Progress in Biophysics and Molecular Biology},
   title = {Modelling the cardiac transverse-axial tubular system},
   volume = {96},
   year = {2008}
}

TY  - JOUR
ID  - 807504
AU  - Pásek, Michal - Šimurda, Jiří - Christé, Georges - Orchard, Clive
PY  - 2008
TI  - Modelling the cardiac transverse-axial tubular system
JF  - Progress in Biophysics and Molecular Biology
VL  - 96
IS  - 1-3
SP  - 226-243
EP  - 226-243
PB  - Elsevier Ltd.
SN  - 00796107
KW  - cardiac cell
KW  - transverse-axial tubular system
KW  - quantitative modelling
N2  - The transverse-axial tubular system (TATS) of cardiac ventricular myocytes is a complex network of tubules that arises as invaginations of the surface membrane; it appears to form a specialised region of cell membrane that is particularly important for excitation-contraction coupling. However much remains unknown about the structure and role of the TATS. In this brief review we use experimental data and computer modelling to address the following key questions: (i) What fraction of the cell membrane is within the TATS? (ii) Is the composition of the TATS membrane the same as the surface membrane? (iii) How good is electrical coupling between the surface and TATS membranes? (iv) What fraction of each current is within the TATS? (v) How important is the complex structure of the TATS network? (vi) What is the effect of current inhomogeneity on lumenal ion concentrations? (vii) Does the TATS contribute to the functional changes observed in heart failure? Although there are many areas in which experimental evidence is lacking, computer models provide a method to assess and predict the possible function of the TATS; such models suggest that although the surface and TATS membranes are electrically well coupled, concentration of ion flux pathways within the TATS, coupled to restricted diffusion, may result in the ionic composition in the TATS lumen being different from that in the bulk extracellular space, and varying with activity and in pathological conditions.
ER  -

PÁSEK, Michal; Jiří ŠIMURDA; Georges CHRISTÉ a Clive ORCHARD. Modelling the cardiac transverse-axial tubular system. \textit{Progress in Biophysics and Molecular Biology}. Great Britain: Elsevier Ltd., 2008, roč.~96, 1-3, s.~226-243, 17 s. ISSN~0079-6107.

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