PÁSEK, Michal. Computer modelling in cardiac cell electrophysiology. Engineering Mechanics. 2007, vol. 15, No 5, p. 365-372. ISSN 1802-1484.
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Basic information
Original name Computer modelling in cardiac cell electrophysiology
Name in Czech Výpočtové modelování v srdeční celulární elektrofyziologii
Authors PÁSEK, Michal.
Edition Engineering Mechanics. 2007, 1802-1484.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
Keywords in English electrophysiology; cardiac cell; quantitative modelling
Tags Cardiac cell, Electrophysiology, Quantitative modelling
Tags International impact, Reviewed
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 9/1/2009 20:07.
Abstract
Experimentally based models of cardiac cells have been developed since 1960. The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology.
Abstract (in Czech)
Práce popisuje dlouhou historii vývoje matematických modelů srdečních buněk a zároveň vystihuje jejich neocenitelnou roli v postupném objasňování složitých elektrofyziologických dějů, které na buněčné úrovni srdečního svalu probíhají.
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