Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin

LOJA, Tomáš, Petr CHLAPEK, Petr KUGLÍK, Martina PEŠÁKOVÁ, Alexandra OLTOVÁ, Pavel CEJPEK and Renata VESELSKÁ. Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin. Oncology Reports. 2009, vol. 21, No 1, p. 119-127. ISSN 1021-335X.

Basic information

Original name

Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear location of nestin

Name in Czech

Charakterizace glioblastomové buněčné linie GM7 vykazující CD133 pozitivitu a cytoplazmatickou i jadernou lokalizaci nestinu

Authors

LOJA, Tomáš (703 Slovakia, belonging to the institution), Petr CHLAPEK (203 Czech Republic, belonging to the institution), Petr KUGLÍK (203 Czech Republic, belonging to the institution), Martina PEŠÁKOVÁ (203 Czech Republic, belonging to the institution), Alexandra OLTOVÁ (203 Czech Republic, belonging to the institution), Pavel CEJPEK (203 Czech Republic, belonging to the institution) and Renata VESELSKÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Oncology Reports, 2009, 1021-335X

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.588

RIV identification code

RIV/00216224:14310/09:00029159

Organization unit

Faculty of Science

UT WoS

000262123200017

Keywords in English

nestin; CD133; intermediate filaments; glioblastoma multiforme; cancer stem cells; immunocytochemistry; transmission electron microscopy

Tags

cancer stem cells, CD133, glioblastoma multiforme, immunocytochemistry, intermediate filaments, nestin, transmission electron microscopy

Tags

International impact, Reviewed

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Abstract

V originále

A detailed characterization of the established GM7 glioblastoma cell line is given in this paper. This cell line was identified as near-triploid and is characterized by nestin+/CD133+ phenotype with unusual localization of nestin both in cytoplasm and cell nucleus.

In Czech

Práce přináší detailní charakterizace stabilizované glioblastomové linie GM7. Tato buněčná linie je near-triploidní a je charakterizována fenotypem nestin+/CD133+ s neobvyklou lokalizací nestinu v cytplazmě i buněčném jádře.

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Links

GD204/08/H054, research and development project	Name: Molekulární mechanismy proliferace a diferenciace buněk Investor: Czech Science Foundation, Molecular mechanisms of the cell proliferation and differentiation
MSM0021622415, plan (intention)	Name: Molekulární podstata buněčných a tkáňových regulací Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
OC B19.001, research and development project	Name: Genová diagnostika a terapie multiformního glioblastomu (Acronym: COST) Investor: Ministry of Education, Youth and Sports of the CR, Gene Diagnostics and Therapy of Multiform Glioblastoma