| BRYJA, Vítězslav, Alexandra SCHAMBONY, Lukáš ČAJÁNEK, Isabel DOMINGUEZ, Ernest ARENAS and Gunnar SCHULTE. Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO REPORTS. 2008, vol. 9, No 12, p. 1244-1250. ISSN 1469-221X. |
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@article{816463,
author = {Bryja, Vítězslav and Schambony, Alexandra and Čajánek, Lukáš and Dominguez, Isabel and Arenas, Ernest and Schulte, Gunnar},
article_number = {12},
keywords = {convergent extension movements; RAC-1; RHO-like GTPases; Xenopus laevis; WNT-5A},
language = {eng},
issn = {1469-221X},
journal = {EMBO REPORTS},
title = {Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways},
volume = {9},
year = {2008}
}
TY - JOUR
ID - 816463
AU - Bryja, Vítězslav - Schambony, Alexandra - Čajánek, Lukáš - Dominguez, Isabel - Arenas, Ernest - Schulte, Gunnar
PY - 2008
TI - Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways
JF - EMBO REPORTS
VL - 9
IS - 12
SP - 1244-1250
EP - 1244-1250
SN - 1469221X
KW - convergent extension movements
KW - RAC-1
KW - RHO-like GTPases
KW - Xenopus laevis
KW - WNT-5A
N2 - Recent advances in understanding beta-catenin-independent WNT (non-canonical) signaling suggest an increasing complexity, opening the question of how individual non-canonical pathways are induced and regulated. Here we examine whether intracellular signaling components such as beta-arrestin and casein kinase 1 and 2 (CK1 and 2) can contribute to determine signaling specificity in beta-catenin-independent WNT signaling to the small GTPase RAC-1. Our results suggest that the balance between beta-arrestin and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated.
ER -
BRYJA, Vítězslav, Alexandra SCHAMBONY, Lukáš ČAJÁNEK, Isabel DOMINGUEZ, Ernest ARENAS and Gunnar SCHULTE. Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. \textit{EMBO REPORTS}. 2008, vol.~9, No~12, p.~1244-1250. ISSN~1469-221X.
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