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@proceedings{816842,
author = {Kovářová, Lucie and Burešová, Ivana and Pour, Luděk and Michálek, Jaroslav and Hájek, Roman},
booktitle = {ASH 2008},
keywords = {plasma cells; monoclonal gammopathy; multiple myeloma; flow cytometry},
language = {eng},
isbn = {ISSN 1528-0020},
title = {Flow Cytometric Detection of Minimal Residual Disease in Multiple Myeloma Patients},
url = {http://abstracts.hematologylibrary.org/cgi/content/abstract/112/11/5141?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=kovarova+L&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT},
year = {2008}
}
TY - CONF
ID - 816842
AU - Kovářová, Lucie - Burešová, Ivana - Pour, Luděk - Michálek, Jaroslav - Hájek, Roman
PY - 2008
TI - Flow Cytometric Detection of Minimal Residual Disease in Multiple Myeloma Patients
SN - ISSN 15280020
KW - plasma cells
KW - monoclonal gammopathy
KW - multiple myeloma
KW - flow cytometry
UR - http://abstracts.hematologylibrary.org/cgi/content/abstract/112/11/5141?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=kovarova+L&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
N2 - Multiple myeloma (MM) is a hematological malignancy characterized by expansion of neoplastic plasma cells (PCs). Despite of advances in treatment, achieved in past ten years, many patients relapse due to minimal residual disease (MRD) existence. In this study number and phenotype of plasma cells in transplanted MM patients was analysed by multiparametric flow cytometry. There is an evidence that relapse is relate to loss of CD19 expression on PCs and to higher number of CD56+ PC. Data acquired in 1st month are not sufficient to predict risk of all patients, because expression of CD19 and CD56 is not representative at this time. Flow cytometric analysis of PCs phenotype profile is relatively quick and sufficiently sensitive method that can be used for monitoring of MRD. Detailed analysis of higher number of patients, later than in 1st month after transplantation, and comparison of their data with other parameters (immunofixation etc.) are necessary for verification of this method and for application in routine diagnostics.
ER -
KOVÁŘOVÁ, Lucie, Ivana BUREŠOVÁ, Luděk POUR, Jaroslav MICHÁLEK a Roman HÁJEK. Flow Cytometric Detection of Minimal Residual Disease in Multiple Myeloma Patients. In \textit{ASH 2008}. 2008. ISSN~1528-0020.
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