BLADÉ, J., P. SONNEVELD, JF. SAN MIGUEL, HJ. SUTHERLAND, Roman HÁJEK, A NAGLER, A SPENCER, T ROBAK, MT CIBEIRA, SH ZHUANG, JL HAROUSSEAU a RZ ORLOWSKI. Pegylated liposomal doxorubicin plus bortezomib in relapsed or refraktory multiple myeloma: efficacy and safety in patients with renal function impairment. Clinical lymphoma & myeloma. Dallas, United States: Cancer Information Group, 2008, roč. 8, č. 6, s. 352-355. ISSN 1557-9190. |
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@article{817650, author = {Bladé, J. and Sonneveld, P. and San Miguel, JF. and Sutherland, HJ. and Hájek, Roman and Nagler, A and Spencer, A and Robak, T and Cibeira, MT and Zhuang, SH and Harousseau, JL and Orlowski, RZ}, article_location = {Dallas, United States}, article_number = {6}, keywords = {doxorubicin;bortezomib}, language = {eng}, issn = {1557-9190}, journal = {Clinical lymphoma & myeloma}, title = {Pegylated liposomal doxorubicin plus bortezomib in relapsed or refraktory multiple myeloma: efficacy and safety in patients with renal function impairment.}, volume = {8}, year = {2008} }
TY - JOUR ID - 817650 AU - Bladé, J. - Sonneveld, P. - San Miguel, JF. - Sutherland, HJ. - Hájek, Roman - Nagler, A - Spencer, A - Robak, T - Cibeira, MT - Zhuang, SH - Harousseau, JL - Orlowski, RZ PY - 2008 TI - Pegylated liposomal doxorubicin plus bortezomib in relapsed or refraktory multiple myeloma: efficacy and safety in patients with renal function impairment. JF - Clinical lymphoma & myeloma VL - 8 IS - 6 SP - 352-355 EP - 352-355 PB - Cancer Information Group SN - 15579190 KW - doxorubicin;bortezomib N2 - A retrospective analysis was undertaken of patients (n = 193) with renal insufficiency (creatinine clearance [CrCl] < 60 mL/min) from a phase III trial comparing bortezomib +/- pegylated liposomal doxorubicin (PLD) in relapsed/refractory myeloma (n = 646). The response rate (49% vs. 42%) and median time to disease progression (331 days vs. 199 days) were comparable or slightly better for patients with renal insufficiency treated with PLD/bortezomib compared with patients treated with bortezomib alone. There was a steady, clinically meaningful improvement in renal function for patients with renal insufficiency in both treatment arms. However, patients with impaired renal function were at a slightly increased risk of a drug-related serious adverse event (28% vs. 19% for CrCl < 60 and > or = 60 mL/min, respectively). ER -
BLADÉ, J., P. SONNEVELD, JF. SAN MIGUEL, HJ. SUTHERLAND, Roman HÁJEK, A NAGLER, A SPENCER, T ROBAK, MT CIBEIRA, SH ZHUANG, JL HAROUSSEAU a RZ ORLOWSKI. Pegylated liposomal doxorubicin plus bortezomib in relapsed or refraktory multiple myeloma: efficacy and safety in patients with renal function impairment. \textit{Clinical lymphoma \&{} myeloma}. Dallas, United States: Cancer Information Group, 2008, roč.~8, č.~6, s.~352-355. ISSN~1557-9190.
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