Další formáty:
BibTeX
LaTeX
RIS
@article{818309, author = {Slanina, Jiří and Březinová, Lenka and Paulová, Hana and Humpa, Otakar}, article_location = {Stuttgart - New York}, article_number = {9}, keywords = {Schisandra chinensis; lignans; DPPH; HPLC}, language = {eng}, issn = {0032-0943}, journal = {Planta Medica}, title = {Antioxidant lignans from petroleum ether extract of Schisandra chinensis}, volume = {74}, year = {2008} }
TY - JOUR ID - 818309 AU - Slanina, Jiří - Březinová, Lenka - Paulová, Hana - Humpa, Otakar PY - 2008 TI - Antioxidant lignans from petroleum ether extract of Schisandra chinensis JF - Planta Medica VL - 74 IS - 9 SP - 952-952 EP - 952-952 PB - Thieme Medical Publishers SN - 00320943 KW - Schisandra chinensis KW - lignans KW - DPPH KW - HPLC N2 - The fruit of Schisandra chinensis, a woody liana, has been used for centuries in traditional Chinese medicine. The fruit is prescribed for the treatment of viral and chemically induced hepatitis in China. Extracts of Schisandra chinensis have demonstrated hepatoprotective and cardioprotective activities, which can be potentially connected with ability to reduce oxidative stress. The aim of our study was to characterise compounds, which correspond for antioxidant activity of Schisandra chinensis. The petroleum ether extract of seeds of Schisandra chinensis showed scavenging activity against the free stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH. The petroleum ether extract was extracted with methanol and the methanolic extract was further chromatographed on silica gel column with petroleum ether, benzene, diethyl ether and ethanol as a mobile phase. The most active fractions eluted with benzene were further fractioned on silica gel column and Sephadex LH-20 column and by semi-preparative RP-HPLC. Bioassay guided fractionation led to the isolation of dibenzylbutane lignan meso-dihydroguaiaretic acid and dibenzo[a,c]cyclooctadiene lignans schisanhenol and gomisin J. All active lignans containing one or two phenolic hydroxyls belong to minor lignan constituents of Schisandra. Together with the active lignans, nine dibenzocyclooctadiene lignans were isolated, namely, schizandrin, deoxyschizandrin, gamma-schizandrin, gomisin A, gomisin N, tigloylgomisin H, angeloylgomisin H, tigloylgomisin P and wuweizisu C. The lignans were identified by spectroscopic methods (1H and 13C NMR, MS). ER -
SLANINA, Jiří, Lenka BŘEZINOVÁ, Hana PAULOVÁ a Otakar HUMPA. Antioxidant lignans from petroleum ether extract of Schisandra chinensis. \textit{Planta Medica}. Stuttgart - New York: Thieme Medical Publishers, 2008, roč.~74, č.~9, s.~952-952. ISSN~0032-0943.
|